DLD3/YEL071W Protein Information

Standard Name	Dld3p
Systematic Name	Yel071wp
ORF Classification	Verified
Description	D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm (1, 2)
Name Description	D-Lactate Dehydrogenase 1

Experimental Data
Molecules/cell	13000 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	496
Molecular Weight (Da)	55,225
Isoelectric Point (pI)	6.88

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Dld3p (InterPro)
Physical Interactions	There are 19 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004F906 \| P39976 MIPS: YEL071W NCBI: 603247 \| 6320764 \| 731427 \| NP_010843.1 \| NM_001178886.1 GenBank/EMBL/DDBJ: DAA07584.1 \| U18795
External Classifications	EC: 1.1.2.4 [D-lactate dehydrogenase (cytochrome)]

Amino Acid Sequence (or in FASTA format)
1 MTAAHPVAQL TAEAYPKVKR NPNFKVLDSE DLAYFRSILS NDEILNSQAP 51 EELASFNQDW MKKYRGQSNL ILLPNSTDKV SKIMKYCNDK KLAVVPQGGN 101 TDLVGASVPV FDEIVLSLRN MNKVRDFDPV SGTFKCDAGV VMRDAHQFLH 151 DHDHIFPLDL PSRNNCQVGG VVSTNAGGLN FLRYGSLHGN VLGLEVVLPN 201 GEIISNINAL RKDNTGYDLK QLFIGAEGTI GVVTGVSIVA AAKPKALNAV 251 FFGIENFDTV QKLFVKAKSE LSEILSAFEF MDRGSIECTI EYLKDLPFPL 301 ENQHNFYVLI ETSGSNKRHD DEKLTAFLKD TTDSKLISEG MMAKDKADFD 351 RLWTWRKSVP TACNSYGGMY KYDMSLQLKD LYSVSAAVTE RLNAAGLIGD 401 APKPVVKSCG YGHVGDGNIH LNIAVREFTK QIEDLLEPFV YEYIASKKGS 451 ISAEHGIGFH KKGKLHYTRS DIEIRFMKDI KNHYDPNGIL NPYKYI*

Amino Acid Sequence (or in FASTA format)

       1  MTAAHPVAQL TAEAYPKVKR NPNFKVLDSE DLAYFRSILS NDEILNSQAP
      51  EELASFNQDW MKKYRGQSNL ILLPNSTDKV SKIMKYCNDK KLAVVPQGGN
     101  TDLVGASVPV FDEIVLSLRN MNKVRDFDPV SGTFKCDAGV VMRDAHQFLH
     151  DHDHIFPLDL PSRNNCQVGG VVSTNAGGLN FLRYGSLHGN VLGLEVVLPN
     201  GEIISNINAL RKDNTGYDLK QLFIGAEGTI GVVTGVSIVA AAKPKALNAV
     251  FFGIENFDTV QKLFVKAKSE LSEILSAFEF MDRGSIECTI EYLKDLPFPL
     301  ENQHNFYVLI ETSGSNKRHD DEKLTAFLKD TTDSKLISEG MMAKDKADFD
     351  RLWTWRKSVP TACNSYGGMY KYDMSLQLKD LYSVSAAVTE RLNAAGLIGD
     401  APKPVVKSCG YGHVGDGNIH LNIAVREFTK QIEDLLEPFV YEYIASKKGS
     451  ISAEHGIGFH KKGKLHYTRS DIEIRFMKDI KNHYDPNGIL NPYKYI*

external links for Dld3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Dld3p

1)	Chelstowska A, et al. (1999) Signalling between mitochondria and the nucleus regulates the expression of a new D-lactate dehydrogenase activity in yeast. Yeast 15(13):1377-91
2)	Tate JJ, et al. (2002) Mks1p is required for negative regulation of retrograde gene expression in Saccharomyces cerevisiae but does not affect nitrogen catabolite repression-sensitive gene expression. J Biol Chem 277(23):20477-82
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41