SIT1/YEL065W Protein Information Help

Standard Name Sit1p 1
Systematic Name Yel065wp
Alias Arn3p 2
ORF Classification Verified
Description Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p (3, 4, 5)
Name Description Siderophore Iron Transport 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 628
Molecular Weight (Da) 70,561
Isoelectric Point (pI) 8.06

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sit1p (InterPro)
Transmembrane Domains There are 14 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 9 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013AC45 | P39980
MIPS: YEL065W
NCBI: 398364221 | 51830303 | 603253 | 731422 | NP_010849.3
GenBank/EMBL/DDBJ: DAA07589.1 | AY723800 | U18795
External Classifications TC: 2.A.1.16 [The Siderophore-Iron Transporter (SIT) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MDPGIANHTL PEEFEEVVVP EMLEKEVGAK VDVKPTLTTS SPAPSYIELI
      51  DPGVHNIEIY AEMYNRPIYR VALFFSLFLI AYAYGLDGNI RYTFQAYATS
     101  SYSQHSLLST VNCIKTVIAA VGQIFFARLS DIFGRFSIMI VSIIFYSMGT
     151  IIESQAVNIT RFAVGGCFYQ LGLTGIILIL EVIASDFSNL NWRLLALFIP
     201  ALPFIINTWI SGNVTSAIDA NWKWGIGMWA FILPLACIPL GICMLHMRYL
     251  ARKHAKDRLK PEFEALNKLK WKSFCIDIAF WKLDIIGMLL ITVFFGCVLV
     301  PFTLAGGLKE EWKTAHIIVP EVIGWVVVLP LYMLWEIKYS RHPLTPWDLI
     351  QDRGIFFALL IAFFINFNWY MQGDYMYTVL VVAVHESIKS ATRITSLYSF
     401  VSVIVGTILG FILIKVRRTK PFIIFGISCW IVSFGLLVHY RGDSGAHSGI
     451  IGSLCLLGFG AGSFTYVTQA SIQASAKTHA RMAVVTSLYL ATYNIGSAFG
     501  SSVSGAVWTN ILPKEISKRI SDPTLAAQAY GSPFTFITTY TWGTPERIAL
     551  VMSYRYVQKI LCIIGLVFCF PLLGCAFMLR NHKLTDSIAL EGNDHLESKN
     601  TFEIEEKEES FLKNKFFTHF TSSKDRKD*

external links for Sit1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome TCDB

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Sit1p
1) Lesuisse E, et al.  (1998) Siderophore-mediated iron uptake in Saccharomyces cerevisiae: the SIT1 gene encodes a ferrioxamine B permease that belongs to the major facilitator superfamily. Microbiology 144 ( Pt 12):3455-62
2) Yun CW, et al.  (2000) Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake. J Biol Chem 275(14):10709-15
3) Philpott CC, et al.  (2002) The response to iron deprivation in Saccharomyces cerevisiae: expression of siderophore-based systems of iron uptake. Biochem Soc Trans 30(4):698-702
4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
5) Haurie V, et al.  (2003) The Snf1 protein kinase controls the induction of genes of the iron uptake pathway at the diauxic shift in Saccharomyces cerevisiae. J Biol Chem 278(46):45391-6