POL5/YEL055C Protein Information Help

Standard Name Pol5p 1
Systematic Name Yel055cp
ORF Classification Verified
Description DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA (2, 3)
Name Description POLymerase 1
Experimental Data
Molecules/cell 4490 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,022
Molecular Weight (Da) 115,893
Isoelectric Point (pI) 5.07

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pol5p (InterPro)
Physical Interactions There are 34 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001297AF | P39985
MIPS: YEL055C
NCBI: 4867912 | 603263 | 6320780 | 731417 | NP_010859.1 | NM_001178870.1
GenBank/EMBL/DDBJ: DAA07599.1 | AB027253 | U18795
External Classifications EC: 2.7.7.7 [DNA-directed DNA polymerase]
Amino Acid Sequence (or in FASTA format)
 
       1  MTGKVNRDLF FKLASDLREE RLHAAVALIK DLSALDLPDD AEEWSYVLNR
      51  LIKGLSSDRN SARLGFSLCL TEVINLAVNM PPGQRPKGLE STNEFLSTLS
     101  TILNVNVNEG TKKSMKGKDE RGILFGKLFG LKSLLNEPLF SEIFVKDLEK
     151  GNTEFFIRFT EQLIDLALKK NWIKEPCFFT LFQTMKMLLP FMDESSAEKI
     201  LLIYDKYDLT LTNEGLSTYL LLKYEGDESL IPSVLDLKNP GWKDNDPLAR
     251  GNLPLLTKVL RNSSVIPDAN GGLKETKKQK NTNWNPRLHF VWSVLLPLFG
     301  NGKLENTSHI SKKRKKTNNK KVQNSIQFPE FWKMAVDESF FNEKASSERK
     351  YLGFLIIDAA FKAVPGSYIG FCFSQNVMRT LINQSIDSQR VLNKISQLTL
     401  DSIVKACEED SANRLVPCLN AMLFGPHGSI NFDKLTKSGT VSKLIAIKEL
     451  PSTVLAQLLD VFFLQLQDKK GVLSHTLFAL DSILHIVRAH KVEINDMDIM
     501  KPVLRPIVYM AFFKHTSDDL KLEQLHELAK ERLYSILGEL TINKEIRCKD
     551  PEINSWQYLT LKLILDIENS HVGDLINPLD ENLENIKNEA ISCLSKVCRS
     601  RTAQSWGLST LLSMCLVQLY AGDTDSISVI EELCEFSKHE NNSMVGITEI
     651  LLSLLAQKKA LLRKLSLIIW QQFIEEVGLE ELQILLDILK ARENKQGFAQ
     701  LFEGEEEFEE IKEENDASED ESKTGSESES ESESDSDDAD EKDEEDEANE
     751  DILNIDKEAT SALVKALNLP DNIVNDKGEV DLDQLEGLSD DGGDDEDEES
     801  MDDEKMMELD DQLSEIFKRR KEALSSISTG NQRKFEVKQS RENVISFKHR
     851  VVDMLAVYVK YCEKLTLANK SEHSNNLGGS LSKLVYFIIP MLKCVNETLD
     901  RPLADKISKL LKGKIFKIKV TAFKDMNKDI ELMDLLKKTH KLMLTSKPGQ
     951  HAAVFYSMCS TSSLFLSKLY VEIGGNDKLD ELIDLYTATT KEWMQKGKCG
    1001  PNIFIDFINW LSSKKQTVMD KE*

external links for Pol5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Pol5p
1) Sugino A  (1995) Yeast DNA polymerases and their role at the replication fork. Trends Biochem Sci 20(8):319-23
2) Shimizu K, et al.  (2002) The fifth essential DNA polymerase phi in Saccharomyces cerevisiae is localized to the nucleolus and plays an important role in synthesis of rRNA. Proc Natl Acad Sci U S A 99(14):9133-8
3) Yang W, et al.  (2003) Yeast POL5 is an evolutionarily conserved regulator of rDNA transcription unrelated to any known DNA polymerases. Cell Cycle 2(2):120-2
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41