RPL12A/YEL054C Protein Information Help

Standard Name Rpl12ap
Systematic Name Yel054cp
ORF Classification Verified
Description Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Ribosomal Protein of the Large subunit
Gene Product L11 5 , L12A 2 , L15A 2 , YL23 2
Experimental Data
Molecules/cell 68500 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 165
Molecular Weight (Da) 17,822
Isoelectric Point (pI) 10.2

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rpl12ap (InterPro)
Physical Interactions There are 79 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000004F901 | P0CX53
MIPS: YEL054C
NCBI: 315113309 | 315113582 | 338819273 | 377656242 | 398366579 | 428697988 | 4386 | 49258849 | 51013853 | 603264 | 6320781 | NP_010706.3 | NP_010860.1 | NM_001178869.1 | NM_001180726.3
GenBank/EMBL/DDBJ: DAA07600.1 | AY693201 | U18795 | X51519
Amino Acid Sequence (or in FASTA format)
 
       1  MPPKFDPNEV KYLYLRAVGG EVGASAALAP KIGPLGLSPK KVGEDIAKAT
      51  KEFKGIKVTV QLKIQNRQAA ASVVPSASSL VITALKEPPR DRKKDKNVKH
     101  SGNIQLDEII EIARQMRDKS FGRTLASVTK EILGTAQSVG CRVDFKNPHD
     151  IIEGINAGEI EIPEN*

external links for Rpl12ap
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB GeneMANIA

YOGY


References cited on this page View Complete Literature Guide for Rpl12ap
1) Briones E, et al.  (1998) The GTPase center protein L12 is required for correct ribosomal stalk assembly but not for Saccharomyces cerevisiae viability. J Biol Chem 273(48):31956-61
2) Planta RJ and Mager WH  (1998) The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14(5):471-7
3) Lecompte O, et al.  (2002) Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain scale. Nucleic Acids Res 30(24):5382-90
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Jenner L, et al.  (2012) Crystal structure of the 80S yeast ribosome. Curr Opin Struct Biol 22(6):759-67
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41