RAD23/YEL037C Protein Information

Standard Name	Rad23p
Systematic Name	Yel037cp
ORF Classification	Verified
Description	Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover (1, 2, 3, 4, 5)
Name Description	RADiation sensitive

Experimental Data
Molecules/cell	10900 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	398
Molecular Weight (Da)	42,366
Isoelectric Point (pI)	4.07

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rad23p (InterPro)
Physical Interactions	There are 176 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053043 \| P32628 MIPS: YEL037C NCBI: 158430391 \| 158430393 \| 158430397 \| 212375047 \| 295322000 \| 347495 \| 347499 \| 398364251 \| 409247 \| 418413 \| 4261672 \| 430824 \| 51013487 \| 603642 \| 71041938 \| 71041940 \| NP_010877.3 GenBank/EMBL/DDBJ: DAA07616.1 \| AY693018 \| L22172 \| L22173 \| L25428 \| S65964 \| S66117 \| U18779

Amino Acid Sequence (or in FASTA format)
1 MVSLTFKNFK KEKVPLDLEP SNTILETKTK LAQSISCEES QIKLIYSGKV 51 LQDSKTVSEC GLKDGDQVVF MVSQKKSTKT KVTEPPIAPE SATTPGRENS 101 TEASPSTDAS AAPAATAPEG SQPQEEQTAT TERTESASTP GFVVGTERNE 151 TIERIMEMGY QREEVERALR AAFNNPDRAV EYLLMGIPEN LRQPEPQQQT 201 AAAAEQPSTA ATTAEQPAED DLFAQAAQGG NASSGALGTT GGATDAAQGG 251 PPGSIGLTVE DLLSLRQVVS GNPEALAPLL ENISARYPQL REHIMANPEV 301 FVSMLLEAVG DNMQDVMEGA DDMVEGEDIE VTGEAAAAGL GQGEGEGSFQ 351 VDYTPEDDQA ISRLCELGFE RDLVIQVYFA CDKNEEAAAN ILFSDHAD*

Amino Acid Sequence (or in FASTA format)

       1  MVSLTFKNFK KEKVPLDLEP SNTILETKTK LAQSISCEES QIKLIYSGKV
      51  LQDSKTVSEC GLKDGDQVVF MVSQKKSTKT KVTEPPIAPE SATTPGRENS
     101  TEASPSTDAS AAPAATAPEG SQPQEEQTAT TERTESASTP GFVVGTERNE
     151  TIERIMEMGY QREEVERALR AAFNNPDRAV EYLLMGIPEN LRQPEPQQQT
     201  AAAAEQPSTA ATTAEQPAED DLFAQAAQGG NASSGALGTT GGATDAAQGG
     251  PPGSIGLTVE DLLSLRQVVS GNPEALAPLL ENISARYPQL REHIMANPEV
     301  FVSMLLEAVG DNMQDVMEGA DDMVEGEDIE VTGEAAAAGL GQGEGEGSFQ
     351  VDYTPEDDQA ISRLCELGFE RDLVIQVYFA CDKNEEAAAN ILFSDHAD*

external links for Rad23p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rad23p

1)	Prakash S and Prakash L (2000) Nucleotide excision repair in yeast. Mutat Res 451(1-2):13-24
2)	Lommel L, et al. (2002) Proteolysis of a nucleotide excision repair protein by the 26 S proteasome. Curr Genet 42(1):9-20
3)	de Laat WL, et al. (1999) Molecular mechanism of nucleotide excision repair. Genes Dev 13(7):768-85
4)	Wang S, et al. (2009) N-terminal deletion of Peptide:N-glycanase results in enhanced deglycosylation activity. PLoS One 4(12):e8335
5)	Li Y, et al. (2010) Rad4 regulates protein turnover at a postubiquitylation step. Mol Biol Cell 21(1):177-85
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41