SSK22/YCR073C Protein Information Help

Standard Name Ssk22p
Systematic Name Ycr073cp
ORF Classification Verified
Description MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication (1, 2, 3)
Name Description Suppressor of Sensor Kinase
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,331
Molecular Weight (Da) 152,716
Isoelectric Point (pI) 7.74

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ssk22p (InterPro)
Physical Interactions There are 36 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000000BFF | P25390
MIPS: YCR073C
NCBI: 10383805 | 14588955 | 45644970 | NP_009998.2
GenBank/EMBL/DDBJ: DAA07544.1 | X59720
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MMMDILNTQQ QKAAEGGRVL APHTISSKLV KRLSSHSSHK LSRSDLKALG
      51  GSETISDGPS QLTFKDRYVF NESLYLKKLK KTALDDYYTR GIKLTNRYEE
     101  DDGDDEIIRL SNGDRIDEDL HSGVKFFSTT PYCRKMRSDS DELAWNEIAT
     151  ERFKWQSMLA RVLKGDIVKG EKTRIANQVK KPGLNKELSD EIWLELKAWL
     201  NGRTMQEMEQ SLTYLRDSSD SVFEEIMKFQ IPQGKILSLD ALEAILQDLM
     251  NRYHSVVSYW PNLKKMYKDK PITNTAEFTA RIDVMNSWLN FKTNLTLRRQ
     301  ELDDWINRFS PISSSDNCQE DFDGVPQWNC KMKILAEQLM KEKNIESIFQ
     351  KKIFYPLSPW MFKLKLHFIV YRETLTKMNI KYPYERLRSL LAFPVYLIKE
     401  VILTRLSYAR KLKNPTMMMI DQMIDDFNAF IRLSVQLKYT LTKYCSNLPF
     451  DVDFDPTFEN TVIEAIRYLF FLLNLKLIDS SKQNFKAPDL LLKYWDHLKN
     501  TGHYINGAET VIPNEFLKLT LRLVHKLQFY LLKQQNFPPT FANASEAEKW
     551  LSSIFENLGA MKRKLNRFSN ILVKAFQNSA VYQINHNAQL VKKLKDAHYF
     601  LVYSGNTFES SGVYMFAAPE LLGCDNDTIL RILRNKSIGC DLVPKLDIGN
     651  NLNVYDITTK ETDLNILVSK GEDSKGIPYY RVVANSSSDL DRHAHQSKKK
     701  NFSTDPFDQH LDEKNNEVFE LEVALSSLGA LVVLYPGEPV VWDGPVYKLP
     751  GNNLFASNEM DLGKIGNPNT LILLNQGSNY ALTYQIDKFN QTVGDSVSFI
     801  EKRCSLNSIE SSLQKINKAY YKLTYTVLNN YKGILGSFMK QCPGNELLNS
     851  IFMFGRDFGR SFLKYNAFSS KRKYVIIFLM VKLGMNWLKF LVEECDPTDQ
     901  RTFRWCVLAM DFAMQMTSGY NILALNVKQF QELKERVSVC MSLLISHFDV
     951  MGARATEAEN GMQQARLNID TEENIDEEAT LEINSRLRLE AIKTLEKTMK
    1001  RNPRQMGKVL DATDQGNKYL LSLASSLSNV SMRWQKRSFI GGGTFGQVYS
    1051  AINLENGEIL AVKEIKIHDT TTMKKIFPLI KEEMTVLEML NHPNIVQYYG
    1101  VEVHRDKVNI FMEYCEGGSL ASLLDHGRIE DEMVTQVYTF ELLEGLAYLH
    1151  QSGVVHRDIK PENILLDFNG IIKYVDFGTA RTVVGSRTRT VRNAAVQDFG
    1201  VETKSLNEMM GTPMYMAPET ISGSAVKGKL GADDVWALGC VVLEMATGRR
    1251  PWSNLDNEWA IMYHVAAGRI PQLPNRDEMT AAGRAFLERC LVQDPTMRAT
    1301  AVELLIDPWM IQIREIAFGN SEKDQVPILS S*

external links for Ssk22p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Ssk22p
1) Posas F and Saito H  (1998) Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator. EMBO J 17(5):1385-94
2) Tatebayashi K, et al.  (2003) A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway. EMBO J 22(14):3624-34
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61