SED4/YCR067C Protein Information Help

Standard Name Sed4p 1
Systematic Name Ycr067cp
ORF Classification Verified
Description Integral ER membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; SED4 has a paralog, SEC12, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Suppressor of Erd2 Deletion 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,065
Molecular Weight (Da) 114,078
Isoelectric Point (pI) 4.45

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sed4p (InterPro)
Physical Interactions There are 6 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000135804 | P25365
MIPS: YCR067C
NCBI: 140524 | 1926401 | 51013803 | 6319912 | NP_009993.1
GenBank/EMBL/DDBJ: DAA07539.1 | AY693176 | X59720
Amino Acid Sequence (or in FASTA format)
 
       1  MSGNSANYDV GYPIYGAKFI NEGTLLVAGG GGQFNSSFPN KITALKVNFQ
      51  KKKHIRRFRE ITLDSIDDAP TSLDCNNNLI LVGCNELFND SSMENVNHHL
     101  RKFVFEQEHL KFVASIDFNR TTDPSVFTKF VYINQRATVA AIASSEVPTV
     151  IRIIDPRNLT ENYEIETGRE VNDLHFAPNG ILLSYITSNS LEVASVRDGN
     201  FVARKTDFDK NLVLSNIRFL NDNTLLVAAS LSNSDGVSLL KLGVSSKGVK
     251  ILKTASFMFD LNGITSMDVS PNKKFVALSS NDNLVAIVSV EKLKLVQLVP
     301  RVHESTITKV TFSPDSRYLA STSMGNTINV LKLSGTSSSI LRNIWKFFLN
     351  FVLLVVLAGA IQLGYKHNVH GFIYKHAHDI YKSKFKENTT IDQGSSSYFT
     401  INDDYRGITE SADIISATDV ASDIETEFSS FDTSTMRTTT EDEQKFVWIS
     451  SSADSQFTSA DIPTSASSSS SSSSSSFYEE SVTNEPIVSS PTSEITKPLA
     501  SPTEPNIVEK PSLPLNSESI DLLSSSSNSI TEYPEPTPDL EEKLSSLIVE
     551  QSESEITTDR ESVSKLLSTE SPSLSHMPSS SSSSLSLSSS LTTSPTTALS
     601  TSTATAVTTT QTNPTNDAAN TSFLDNSKPA STREIYKTKI ITEVITKIEY
     651  RNIPASDSNA EAEQYVTTSS SMLLTPTDTM VSSPVSEIDP IASELERMVE
     701  TPTHSISIAS EFDSVASNLI PNEEILSTSA SQDSISSHPS TFSDSSITSG
     751  FQSIEVSTVT SSVLASESIP SISDSTFSKF HSISEPVSSA IVETATSSFS
     801  KTETKTSRVI AFSTEDSERS SALIDNSEYT SVLADNLEPT SVLADNSEPT
     851  SVLADSSEPT SVFTDAVQSP KTSVGQSSLS ESTNIEGTSM ASMIFSSSGA
     901  SIGALSDIGK GTLSVESASS TVAQPMPGVT TTAPSFVSSP HKISASSIDA
     951  SGFVQKEIMI EVQSSKDSSE AFGVRHKISE NVNTPVSRML TTEMQASGTV
    1001  DVTEDVSLSS EVISALNVEI TSLPNPVAPP QTIAAPLNNN SNTNIVNDDN
    1051  AVAGTVNYAG LHDEL*

external links for Sed4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Sed4p
1) Hardwick KG, et al.  (1992) Genes that allow yeast cells to grow in the absence of the HDEL receptor. EMBO J 11(11):4187-95
2) Gimeno RE, et al.  (1995) SED4 encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation. J Cell Biol 131(2):325-38
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Kodera C, et al.  (2011) Sed4p stimulates sar1p GTP hydrolysis and promotes limited coat disassembly. Traffic 12(5):591-9