PWP2/YCR057C Protein Information Help

Standard Name Pwp2p 1
Systematic Name Ycr057cp
Alias Ycr055cp 1 , Ycr058cp 1 , Utp1p 2
ORF Classification Verified
Description Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis (1, 3)
Name Description Periodic tryptophan (W) Protein 1
Experimental Data
Molecules/cell 16700 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 923
Molecular Weight (Da) 103,982
Isoelectric Point (pI) 4.79

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pwp2p (InterPro)
Physical Interactions There are 319 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053025 | P25635
MIPS: YCR057C
NCBI: 1907198 | 475231 | 6319903 | 730431 | NP_009984.1 | NM_001178769.1
GenBank/EMBL/DDBJ: DAA07532.1 | X59720 | X78964
Amino Acid Sequence (or in FASTA format)
 
       1  MKSDFKFSNL LGTVYRQGNI TFSDDGKQLL SPVGNRVSVF DLINNKSFTF
      51  EYEHRKNIAA IDLNKQGTLL ISIDEDGRAI LVNFKARNVL HHFNFKEKCS
     101  AVKFSPDGRL FALASGRFLQ IWKTPDVNKD RQFAPFVRHR VHAGHFQDIT
     151  SLTWSQDSRF ILTTSKDLSA KIWSVDSEEK NLAATTFNGH RDYVMGAFFS
     201  HDQEKIYTVS KDGAVFVWEF TKRPSDDDDN ESEDDDKQEE VDISKYSWRI
     251  TKKHFFYANQ AKVKCVTFHP ATRLLAVGFT SGEFRLYDLP DFTLIQQLSM
     301  GQNPVNTVSV NQTGEWLAFG SSKLGQLLVY EWQSESYILK QQGHFDSTNS
     351  LAYSPDGSRV VTASEDGKIK VWDITSGFCL ATFEEHTSSV TAVQFAKRGQ
     401  VMFSSSLDGT VRAWDLIRYR NFRTFTGTER IQFNCLAVDP SGEVVCAGSL
     451  DNFDIHVWSV QTGQLLDALS GHEGPVSCLS FSQENSVLAS ASWDKTIRIW
     501  SIFGRSQQVE PIEVYSDVLA LSMRPDGKEV AVSTLKGQIS IFNIEDAKQV
     551  GNIDCRKDII SGRFNQDRFT AKNSERSKFF TTIHYSFDGM AIVAGGNNNS
     601  ICLYDVPNEV LLKRFIVSRN MALNGTLEFL NSKKMTEAGS LDLIDDAGEN
     651  SDLEDRIDNS LPGSQRGGDL STRKMRPEVR VTSVQFSPTA NAFAAASTEG
     701  LLIYSTNDTI LFDPFDLDVD VTPHSTVEAL REKQFLNALV MAFRLNEEYL
     751  INKVYEAIPI KEIPLVASNI PAIYLPRILK FIGDFAIESQ HIEFNLIWIK
     801  ALLSASGGYI NEHKYLFSTA MRSIQRFIVR VAKEVVNTTT DNKYTYRFLV
     851  STDGSMEDGA ADDDEVLLKD DADEDNEENE ENDVVMESDD EEGWIGFNGK
     901  DNKLPLSNEN DSSDEEENEK ELP*

external links for Pwp2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Pwp2p
1) Shafaatian R, et al.  (1996) PWP2, a member of the WD-repeat family of proteins, is an essential Saccharomyces cerevisiae gene involved in cell separation. Mol Gen Genet 252(1-2):101-14
2) Dragon F, et al.  (2002) A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature 417(6892):967-70
3) Dosil M and Bustelo XR  (2004) Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particle. J Biol Chem 279(36):37385-97
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41