RRT12/YCR045C Protein Information

Standard Name	Rrt12p 1
Systematic Name	Ycr045cp
Alias	Osw3p 2, 3
ORF Classification	Verified
Description	Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores (1, 3, 4)
Name Description	Regulator of rDNA Transcription 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	491
Molecular Weight (Da)	55,068
Isoelectric Point (pI)	5.15

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rrt12p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013A71A \| P25381 MIPS: YCR045C NCBI: 140497 \| 1907187 \| 6319893 \| NP_009974.1 \| NM_001178759.1 GenBank/EMBL/DDBJ: DAA07523.1 \| X59720
External Classifications	EC: 3.4.21.- [Serine endopeptidases]

Amino Acid Sequence (or in FASTA format)
1 MKPQCILISL LVNLAYAEEY LVRFKNPTAF QQFTSNSNRS WRQFIDNKIE 51 KKFSIGSFRG VTMNLSKNLV NKLKKSPLVA DIVPNFRFEA FEGDSVNSAE 101 SSYTFNATAK YSYEDVEEEQ NITYQPDAPR HLARISRHYQ LPFDVGDKDR 151 YKSWFNYYYE HDYQGQDVNA YIMDTGIFAD HPEFEDRVIQ GIDLTKEGFG 201 DQNGHGTHVA GLVGSKTYGA AKRVNLVEVK VLGKDGSGEA SNVLSGLEFI 251 VEHCTKVSRP QGKKCVANLS LGSFRSPIIN MAVEGAIEEG IVFVAAAGNF 301 NLDAYWASPA SAENVITVGA FDDHIDTIAK FSNWGPCVNI FAPGVEIESL 351 SHLNYNDTLI LSGTSMSTPI VTGVAAILLS KGIEPEMIAQ EIEYLSTRNV 401 FHRRTLFFKP STPNQILYNG VDKLDDPYDD ETFPRLNIEA IAKELEEYNA 451 TLQTPMSENL QSGSKLWGWN NDVTLPLGEI RLKRRDFMKN L*

Amino Acid Sequence (or in FASTA format)

       1  MKPQCILISL LVNLAYAEEY LVRFKNPTAF QQFTSNSNRS WRQFIDNKIE
      51  KKFSIGSFRG VTMNLSKNLV NKLKKSPLVA DIVPNFRFEA FEGDSVNSAE
     101  SSYTFNATAK YSYEDVEEEQ NITYQPDAPR HLARISRHYQ LPFDVGDKDR
     151  YKSWFNYYYE HDYQGQDVNA YIMDTGIFAD HPEFEDRVIQ GIDLTKEGFG
     201  DQNGHGTHVA GLVGSKTYGA AKRVNLVEVK VLGKDGSGEA SNVLSGLEFI
     251  VEHCTKVSRP QGKKCVANLS LGSFRSPIIN MAVEGAIEEG IVFVAAAGNF
     301  NLDAYWASPA SAENVITVGA FDDHIDTIAK FSNWGPCVNI FAPGVEIESL
     351  SHLNYNDTLI LSGTSMSTPI VTGVAAILLS KGIEPEMIAQ EIEYLSTRNV
     401  FHRRTLFFKP STPNQILYNG VDKLDDPYDD ETFPRLNIEA IAKELEEYNA
     451  TLQTPMSENL QSGSKLWGWN NDVTLPLGEI RLKRRDFMKN L*

external links for Rrt12p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Rrt12p

1)	Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19
2)	Neiman and Aaron (2009) personal communication
3)	Suda Y, et al. (2009) A screen for spore wall permeability mutants identifies a secreted protease required for proper spore wall assembly. PLoS One 4(9):e7184
4)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91