BPH1/YCR032W Protein Information

Standard Name	Bph1p
Systematic Name	Ycr032wp
ORF Classification	Verified
Description	Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting (1, 2)
Name Description	Beige Protein Homolog 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	2,167
Molecular Weight (Da)	250,870
Isoelectric Point (pI)	6.41

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Bph1p (InterPro)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006BC39 \| P25356 MIPS: YCR032W NCBI: 10383794 \| 14588943 \| 244238 \| 32363487 \| 4806 \| 4809 \| NP_009961.2 GenBank/EMBL/DDBJ: DAA07511.1 \| S78624 \| X59075 \| X59720 \| X62452

Amino Acid Sequence (or in FASTA format)
1 MNSIINAASK VLRLQDDVKK ATIILGDILI LQPINHEVEP DVENLVQHEL 51 TKIIQGYPIQ DNMIINSKKG TVEDDLCELN NYTCFALSKS FDLCHDSRNF 101 NIAQPKRWIQ LLETLTDSVS FAVIVQIILT LSNISLINKQ TLGKLKKLRI 151 RIFEILSNKN DSWKSTLLQK NLIEWYIFML SVDCTPLELQ NLYLHKELKF 201 CNGILNSLTL QVSDPRSQNY LQFENTYKLF QIQKSSRINN SFLFYIEFNS 251 VTSNRIMTIE RHIYLEIKEG QFCISNDNYI IGLFENFEFE AGTLYFIGVL 301 IDHNNRITLY VDGSMINQLT LFENSICQLS TCELGSMICS IKVYRFYLWD 351 GLLTEFAINI LQAIGTNYQY TFSKKKEGPE VLSLCQDFLI AKAHLMARPT 401 TEISSTKYID EIELLEMENI IIDVNPNDIL QDFTESSNFT VKFEESTNSK 451 NIPEVGKCYF YRSSNLVSKF VSIDSIRLAF LNMTESGSID DLFHHVSHLM 501 NLLRNIDILN WFKKDFGFPL FAYTLKQKIT QDLSQPLNIQ FFNLFLEFCG 551 WDFNDISKSI ILDTDAYENI VLNLDLWYMN EDQSSLASGG LEIIRFLFFQ 601 ISSLMEASIY SKFNSNKFND MNILEKLCLS YQAVTKRENQ NSKFNELSSD 651 LISVFVTLLK SNTDKRHLQW FLHLSYYFIK RKDVRSTEII LQAVDQLFSF 701 YLDQGSDENA KILSEIIPLK LILMIMDQIV ENNESNPITC LNILFKVVLT 751 NKPLFKQFYK NDGLKLILTM LCKVGKSYRE EIISLLLTYS IGNYTTANEI 801 FSGAEDMIGG ISNDKITAKE IIYLAVNFIE WHVINSNASD SSSVLDLNNH 851 ILRFVEDLKS LSAVPINESV FDPKKSYVMV SLLDLSIALN ESEDISKFKS 901 SSKVISELIK GNIMCALTKY AAYDFEVYMS TFFCHSTEYK LVYPKTVMNN 951 SSYLELSFIV TLLPEILNDL VDSNNNLNLM MLKHPYTMSN LLYFLRKFRP 1001 DTSQIVMPKD FYFSSYTCLL HCVIQIDKSS FYHFKNVSKS QLLQDFKICI 1051 MNLIYSNTLK QIIWEKEEYE MFSESLMAHQ EVLFAHGACD NETVGLLLIF 1101 FANRLRDCGY NKAVFNCMKV IIKNKERKLK EVACFFDPAN KSEVLEGLSN 1151 ILSCNNSETM NLITEQYPFF FNNTQQVRFI NIVTNILFKN NNFSPISVRQ 1201 IKNQVYEWKN ARSEYVTQNN KKCLILFRKD NTSLDFKIKK SISRYTYNLK 1251 TDREENAVFY RNNLNLLIFH LKHTLEIQSN PNSSCKWSSD FAEDFDGMKR 1301 RLLPAWEPKY EPLINEEDAN QDTITGGNRQ RRESGSILSY EFIEHMETLE 1351 SEPVGDLNEN RKILRLLKDN DSIATIWNCS LIIGLEIKEG ILIHGSNYLY 1401 FVSDYYFSLE DKKILKLSEV SQESRDMTVS LINGPDVKRV STFLKHEVFV 1451 WKLLDITFVT KRPFLLRDVA IELLFKERVS AFFSFYNKRV RDDVLRVLNK 1501 IPKHLPADPI FSSVLQEIND RGNSIVARNG IGKASIASKF TSVFSANNSL 1551 IDGFEISKKW VRGEISNFYY LLSINILAGR SFNDLTQYPV FPWVIADYES 1601 NVLDLENPKT YRDLSKPMGA QSEKRKLQFI ERYEALASLE NADSAPFHYG 1651 THYSSAMIVS SYLIRLKPFV ESFLLLQGGS FGPADRLFSS LERAWSSASS 1701 ENTTDVRELT PEFFFLPEFL INVNSYDFGT DQSGKKVDDV VLPPWANGDP 1751 KVFIQKNREA LESPYVSAHL HEWIDLIFGY KQKGDIAVKS VNVFNRLSYP 1801 GAVNLDNIDD ENERRAITGI IHNFGQTPLQ IFQEPHPEKI ACNVQQLTTE 1851 VWRKVPMKPI FEKTIFNLNE KNRSVDYVIH DPSYFDSLYW RGFAFPNLFF 1901 RTEESLVSLR IVHKNWLKIG LDIFKKTHMA QITSFAYWKL GEFITGDKNG 1951 LIKVWKYRKD KHSVSGNLEN KKTMFGHLCE LKEMRCYHDY NTLLTLDISG 2001 LVYVWDMINF ELVRQITNDA QKVAISQHAG SIMVLTKNNA ISIFNLNGQI 2051 YTSKKFEPAK IVSSIDFFDF TKLDAGYRKH IYWKEMEILL VGFEDGTIEI 2101 YELFLNFHNE WAIKLLKQLC TEKGKAITSI KGQGKTYLSQ KRRKDTAEPH 2151 EIEVIAGTLD GRLAIWY*

Amino Acid Sequence (or in FASTA format)

       1  MNSIINAASK VLRLQDDVKK ATIILGDILI LQPINHEVEP DVENLVQHEL
      51  TKIIQGYPIQ DNMIINSKKG TVEDDLCELN NYTCFALSKS FDLCHDSRNF
     101  NIAQPKRWIQ LLETLTDSVS FAVIVQIILT LSNISLINKQ TLGKLKKLRI
     151  RIFEILSNKN DSWKSTLLQK NLIEWYIFML SVDCTPLELQ NLYLHKELKF
     201  CNGILNSLTL QVSDPRSQNY LQFENTYKLF QIQKSSRINN SFLFYIEFNS
     251  VTSNRIMTIE RHIYLEIKEG QFCISNDNYI IGLFENFEFE AGTLYFIGVL
     301  IDHNNRITLY VDGSMINQLT LFENSICQLS TCELGSMICS IKVYRFYLWD
     351  GLLTEFAINI LQAIGTNYQY TFSKKKEGPE VLSLCQDFLI AKAHLMARPT
     401  TEISSTKYID EIELLEMENI IIDVNPNDIL QDFTESSNFT VKFEESTNSK
     451  NIPEVGKCYF YRSSNLVSKF VSIDSIRLAF LNMTESGSID DLFHHVSHLM
     501  NLLRNIDILN WFKKDFGFPL FAYTLKQKIT QDLSQPLNIQ FFNLFLEFCG
     551  WDFNDISKSI ILDTDAYENI VLNLDLWYMN EDQSSLASGG LEIIRFLFFQ
     601  ISSLMEASIY SKFNSNKFND MNILEKLCLS YQAVTKRENQ NSKFNELSSD
     651  LISVFVTLLK SNTDKRHLQW FLHLSYYFIK RKDVRSTEII LQAVDQLFSF
     701  YLDQGSDENA KILSEIIPLK LILMIMDQIV ENNESNPITC LNILFKVVLT
     751  NKPLFKQFYK NDGLKLILTM LCKVGKSYRE EIISLLLTYS IGNYTTANEI
     801  FSGAEDMIGG ISNDKITAKE IIYLAVNFIE WHVINSNASD SSSVLDLNNH
     851  ILRFVEDLKS LSAVPINESV FDPKKSYVMV SLLDLSIALN ESEDISKFKS
     901  SSKVISELIK GNIMCALTKY AAYDFEVYMS TFFCHSTEYK LVYPKTVMNN
     951  SSYLELSFIV TLLPEILNDL VDSNNNLNLM MLKHPYTMSN LLYFLRKFRP
    1001  DTSQIVMPKD FYFSSYTCLL HCVIQIDKSS FYHFKNVSKS QLLQDFKICI
    1051  MNLIYSNTLK QIIWEKEEYE MFSESLMAHQ EVLFAHGACD NETVGLLLIF
    1101  FANRLRDCGY NKAVFNCMKV IIKNKERKLK EVACFFDPAN KSEVLEGLSN
    1151  ILSCNNSETM NLITEQYPFF FNNTQQVRFI NIVTNILFKN NNFSPISVRQ
    1201  IKNQVYEWKN ARSEYVTQNN KKCLILFRKD NTSLDFKIKK SISRYTYNLK
    1251  TDREENAVFY RNNLNLLIFH LKHTLEIQSN PNSSCKWSSD FAEDFDGMKR
    1301  RLLPAWEPKY EPLINEEDAN QDTITGGNRQ RRESGSILSY EFIEHMETLE
    1351  SEPVGDLNEN RKILRLLKDN DSIATIWNCS LIIGLEIKEG ILIHGSNYLY
    1401  FVSDYYFSLE DKKILKLSEV SQESRDMTVS LINGPDVKRV STFLKHEVFV
    1451  WKLLDITFVT KRPFLLRDVA IELLFKERVS AFFSFYNKRV RDDVLRVLNK
    1501  IPKHLPADPI FSSVLQEIND RGNSIVARNG IGKASIASKF TSVFSANNSL
    1551  IDGFEISKKW VRGEISNFYY LLSINILAGR SFNDLTQYPV FPWVIADYES
    1601  NVLDLENPKT YRDLSKPMGA QSEKRKLQFI ERYEALASLE NADSAPFHYG
    1651  THYSSAMIVS SYLIRLKPFV ESFLLLQGGS FGPADRLFSS LERAWSSASS
    1701  ENTTDVRELT PEFFFLPEFL INVNSYDFGT DQSGKKVDDV VLPPWANGDP
    1751  KVFIQKNREA LESPYVSAHL HEWIDLIFGY KQKGDIAVKS VNVFNRLSYP
    1801  GAVNLDNIDD ENERRAITGI IHNFGQTPLQ IFQEPHPEKI ACNVQQLTTE
    1851  VWRKVPMKPI FEKTIFNLNE KNRSVDYVIH DPSYFDSLYW RGFAFPNLFF
    1901  RTEESLVSLR IVHKNWLKIG LDIFKKTHMA QITSFAYWKL GEFITGDKNG
    1951  LIKVWKYRKD KHSVSGNLEN KKTMFGHLCE LKEMRCYHDY NTLLTLDISG
    2001  LVYVWDMINF ELVRQITNDA QKVAISQHAG SIMVLTKNNA ISIFNLNGQI
    2051  YTSKKFEPAK IVSSIDFFDF TKLDAGYRKH IYWKEMEILL VGFEDGTIEI
    2101  YELFLNFHNE WAIKLLKQLC TEKGKAITSI KGQGKTYLSQ KRRKDTAEPH
    2151  EIEVIAGTLD GRLAIWY*

external links for Bph1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Bph1p

1)	Perou CM, et al. (1996) Complementation of the beige mutation in cultured cells by episomally replicating murine yeast artificial chromosomes. Proc Natl Acad Sci U S A 93(12):5905-9
2)	Shiflett SL, et al. (2004) Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting. Traffic 5(9):700-10