RPS14A/YCR031C Protein Information Help

Standard Name Rps14ap
Systematic Name Ycr031cp
Alias Cry1p 1, 2 , Rpl59p
ORF Classification Verified
Description Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication (3, 4, 5, 6, 7, 8)
Name Description Ribosomal Protein of the Small subunit
Gene Product S11 8 , S14A 9 , rp59A 9
Experimental Data
Molecules/cell 29600 10
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 137
Molecular Weight (Da) 14,537
Isoelectric Point (pI) 11.43

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rps14ap (InterPro)
Physical Interactions There are 111 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006A3E3 | P06367
MIPS: YCR031C
NCBI: 10383793 | 14588942 | 171322 | 313103674 | 315113455 | 315113483 | 364506110 | 364506148 | 46397814 | 49258830 | NP_009960.2
GenBank/EMBL/DDBJ: DAA07510.1 | M16126 | X59720
Amino Acid Sequence (or in FASTA format)
 
       1  MSNVVQARDN SQVFGVARIY ASFNDTFVHV TDLSGKETIA RVTGGMKVKA
      51  DRDESSPYAA MLAAQDVAAK CKEVGITAVH VKIRATGGTR TKTPGPGGQA
     101  ALRALARSGL RIGRIEDVTP VPSDSTRKKG GRRGRRL*

external links for Rps14ap
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS
Candida (CGD) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Rps14ap
1) Larkin JC and Woolford JL Jr  (1983) Molecular cloning and analysis of the CRY1 gene: a yeast ribosomal protein gene. Nucleic Acids Res 11(2):403-20
2) Himmelfarb HJ, et al.  (1984) Molecular cloning and biosynthetic regulation of cry1 gene of Saccharomyces cerevisiae. Mol Gen Genet 195(3):500-6
3) Larkin JC, et al.  (1987) Structure and expression of the Saccharomyces cerevisiae CRY1 gene: a highly conserved ribosomal protein gene. Mol Cell Biol 7(5):1764-75
4) Moritz M, et al.  (1990) Depletion of yeast ribosomal proteins L16 or rp59 disrupts ribosome assembly. J Cell Biol 111(6 Pt 1):2261-74
5) Lecompte O, et al.  (2002) Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain scale. Nucleic Acids Res 30(24):5382-90
6) Jakovljevic J, et al.  (2004) The carboxy-terminal extension of yeast ribosomal protein S14 is necessary for maturation of 43S preribosomes. Mol Cell 14(3):331-42
7) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
8) Jenner L, et al.  (2012) Crystal structure of the 80S yeast ribosome. Curr Opin Struct Biol 22(6):759-67
9) Planta RJ and Mager WH  (1998) The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14(5):471-7
10) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41