FEN2/YCR028C Protein Information Help

Standard Name Fen2p
Systematic Name Ycr028cp
ORF Classification Verified
Description Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress (1, 2)
Name Description FENpropimorph resistance
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 512
Molecular Weight (Da) 58,256
Isoelectric Point (pI) 7.2

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Fen2p (InterPro)
Transmembrane Domains There are 12 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 8 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012A620 | P25621
MIPS: YCR028C
NCBI: 140479 | 1907172 | 6319876 | NP_009957.1
GenBank/EMBL/DDBJ: DAA07507.1 | X59720
External Classifications TC: 2.A.1.14 [The Anion: Cation Symporter (ACS) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MMKESKSITQ HEVERESVSS KRAIKKRLLL FKIDLFVLSF VCLQYWINYV
      51  DRVGFTNAYI SGMKEDLKMV GNDLTVSNTV FMIGYIVGMV PNNLMLLCVP
     101  PRIWLSFCTF AWGLLTLGMY KVTSFKHICA IRFFQALFES CTFSGTHFVL
     151  GSWYKEDELP IRSAIFTGSG LVGSMFSGFM QTSIFTHLNG RNGLAGWRWL
     201  FIIDFCITLP IAIYGFIFFP GLPDQTSAVS KFSMTRYIFN EQELHYARRR
     251  LPARDESTRL DWSTIPRVLK RWHWWMFSLV WVLGGENLGF ASNSTFALWL
     301  QNQKYTLAQR NNYPSGIFAV GIVSTLCSAV YMSKIPRARH WHVSVFISLV
     351  MVIVAVLIRA DPLNPKVVFS AQYLGGVAYA GQAVFFSWAN IICHADLQER
     401  AIVLASMNMF SGAVNAWWSI LFFASDMVPK FERGCYALLA TAISSGIVSV
     451  VIRSLQIKEN LSKKQVPYID ANDMPGEDDD DDNQDNENDG DDESMEVELH
     501  NEEMAEISNP FR*

external links for Fen2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome TCDB
YGOB DIP YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Fen2p
1) Stolz J and Sauer N  (1999) The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter. J Biol Chem 274(26):18747-52
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76