CDC10/YCR002C Protein Information Help

Standard Name Cdc10p
Systematic Name Ycr002cp
ORF Classification Verified
Description Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress (1, 2, 3, 4, 5, 6, 7, 8, 9)
Name Description Cell Division Cycle 10
Experimental Data
Molecules/cell 14100 11
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 322
Molecular Weight (Da) 37,025
Isoelectric Point (pI) 5.55

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cdc10p (InterPro)
Physical Interactions There are 100 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052F43 | P25342
MIPS: YCR002C
NCBI: 115953 | 1907145 | 295592 | 4261556 | 6319847 | NP_009928.1 | NM_001178715.1
GenBank/EMBL/DDBJ: DAA07481.1 | L16549 | S48552 | X59720
Amino Acid Sequence (or in FASTA format)
 
       1  MDPLSSVQPA SYVGFDTITN QIEHRLLKKG FQFNIMVVGQ SGLGKSTLIN
      51  TLFASHLIDS ATGDDISALP VTKTTEMKIS THTLVEDRVR LNINVIDTPG
     101  FGDFIDNSKA WEPIVKYIKE QHSQYLRKEL TAQRERFITD TRVHAILYFL
     151  QPNGKELSRL DVEALKRLTE IANVIPVIGK SDTLTLDERT EFRELIQNEF
     201  EKYNFKIYPY DSEELTDEEL ELNRSVRSII PFAVVGSENE IEINGETFRG
     251  RKTRWSAINV EDINQCDFVY LREFLIRTHL QDLIETTSYI HYEGFRARQL
     301  IALKENANSR SSAHMSSNAI QR*

external links for Cdc10p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Cdc10p
1) Takizawa PA, et al.  (2000) Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier. Science 290(5490):341-4
2) Gladfelter AS, et al.  (2001) The septin cortex at the yeast mother-bud neck. Curr Opin Microbiol 4(6):681-9
3) Hanrahan J and Snyder M  (2003) Cytoskeletal activation of a checkpoint kinase. Mol Cell 12(3):663-73
4) Versele M, et al.  (2004) Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae. Mol Biol Cell 15(10):4568-83
5) Vrabioiu AM, et al.  (2004) The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. J Biol Chem 279(4):3111-8
6) Bertin A, et al.  (2010) Phosphatidylinositol-4,5-bisphosphate Promotes Budding Yeast Septin Filament Assembly and Organization. J Mol Biol 404(4):711-31
7) McMurray MA, et al.  (2011) Septin filament formation is essential in budding yeast. Dev Cell 20(4):540-9
8) Wloka C, et al.  (2011) Evidence that a septin diffusion barrier is dispensable for cytokinesis in budding yeast. Biol Chem 392(8-9):813-829
9) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
10) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9
11) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41