GID7/YCL039W Protein Information Help

Standard Name Gid7p 1
Systematic Name Ycl039wp
Alias Moh2p
ORF Classification Verified
Description Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions (1, 2, 3)
Name Description Glucose Induced Degradation deficient 1, 2
Experimental Data
Molecules/cell 1200 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 745
Molecular Weight (Da) 84,516
Isoelectric Point (pI) 6.11

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Gid7p (InterPro)
Physical Interactions There are 19 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001682CC | P25569
MIPS: YCL039W
NCBI: 114152809 | 140372 | 1907121 | 6319810 | NP_009891.1
GenBank/EMBL/DDBJ: DAA07445.1 | X59720
Amino Acid Sequence (or in FASTA format)
 
       1  MSHTNKIAYV LNNDTEETAS PSSVGCFDKK QLTKLLIHTL KELGYDSAAN
      51  QLLLESGGYQ NESNHIQTFF KLIKTGQFHL INWQIVCSLP LAHSSPLRSE
     101  WLQRLLIPTP TPATTSLFDH MLLQLQYLQQ LMSSVNSSTC SDAEIATLRN
     151  YVEIMILVNR QIFLEFFHPV TNSASHKGPH TALPVLYLRK ILKNFIEIWD
     201  SLLVSNDQFL NEENIFNPET TLRELSTYLT NPKLTAQLNL ERDHLIDAIS
     251  KYIDPNELVP KGRLLHLLKQ AIKYQQSQDI FNIIDPDDDA SFSSPPHRIN
     301  LLQDNFSHDL TVTFQEWKTI QDTTDEIWFL TFSPNGKYLA SATSESSRGY
     351  FITVYDVEQD FKIYKTCVSL SQSVLYLMFS PDSRYLVACP FSEDVTIYDM
     401  NATSLPDASA TDSFLLYPST RLSPMDSFKL DTTTYPDDTE SSASSSSRPA
     451  NANSNQSRVW CCDAFHTAER AGWMVVGSPD REAIVHSLTT KESLFSLKGR
     501  TCIALGHDEN ISGRKSIDPA KVLYKPTSSN GNWQYVEDDE TFPRVHDVKI
     551  SYDDKYVLLM THQGVIDVYD FSGFPSKEEL SKQTVDPKNF LIPRIARLDV
     601  GKNMTCISLP LNTTHQGFHR QQISESQHLV LVSLQDNELQ MWDYKENILI
     651  QKYFGQKQQH FIIRSCFAYG NKLVMSGSED GKIYIWDRIR GNLVSVLSGH
     701  STVMSNSTKP MGKNCNVVAS NPADKEMFAS GGDDGKIKIW KISRN*

external links for Gid7p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Gid7p
1) Samanta MP and Liang S  (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
2) Regelmann J, et al.  (2003) Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways. Mol Biol Cell 14(4):1652-63
3) Menssen R, et al.  (2012) Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. J Biol Chem 287(30):25602-14
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41