ATG22/YCL038C Protein Information

Standard Name	Atg22p 1
Systematic Name	Ycl038cp
Alias	Aut4p 2
ORF Classification	Verified
Description	Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation (3, 4, 5)
Name Description	AuTophaGy related 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	528
Molecular Weight (Da)	58,843
Isoelectric Point (pI)	8.59

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Atg22p (InterPro)
Transmembrane Domains	There are 10 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013A5D4 \| P25568 MIPS: YCL038C NCBI: 140371 \| 5325 \| 6319811 \| NP_009892.1 \| NM_001178683.1 GenBank/EMBL/DDBJ: DAA07446.1 \| X59720
External Classifications	TC: 2.A.1.24 [The Unknown Major Facilitator-1 (UMF1) Family]

Amino Acid Sequence (or in FASTA format)
1 MSYGTINDMN ESVTNYRIKK AQNNIKGWYA YSFSSEPFVV SAVSTYIPLL 51 LQQFASINGV KVHDHSIPCL SETGSDSDKC VLGLFNNRIF VDTSSFALYV 101 FSLSVLFQTI IVISVSGIVD LWGSVKFKGR ILVWFGIVGA LSTVAISKLN 151 DTQIYSLAGL YIVANGCFGV INVVGNSLLP IFVKDSLKCQ SQGAYEPDKV 201 DSLTTVISGR GASLGYSSAL IVQIVSMFLV ASKKGSKQDV QVAVLFVGIW 251 WFVWQLPMIW LIDDVTIPIR VDDSTLASAR SPYPGEQDAL GQLNWKNYLS 301 YGWVSLFESF KHARLLKDVM IFLIAWFIIS DSITTINSTA VLFSKAELHM 351 STLNLIMISV LTVVNAMLGA FMIPQFLATK FRWTSSQTLM YIIIWASFIP 401 FYGILGFFFN AFGLKHKFEM FLLAIWYGLS LGGLSAVSRS VFSLIVPPGK 451 ESTFFSMFSI TDKGSSILGP FLVGLLTDKT HNIRYSFYFF FLLLMLSLPV 501 LNCLDVKRGR REAEELSQVL PESERRLD*

Amino Acid Sequence (or in FASTA format)

       1  MSYGTINDMN ESVTNYRIKK AQNNIKGWYA YSFSSEPFVV SAVSTYIPLL
      51  LQQFASINGV KVHDHSIPCL SETGSDSDKC VLGLFNNRIF VDTSSFALYV
     101  FSLSVLFQTI IVISVSGIVD LWGSVKFKGR ILVWFGIVGA LSTVAISKLN
     151  DTQIYSLAGL YIVANGCFGV INVVGNSLLP IFVKDSLKCQ SQGAYEPDKV
     201  DSLTTVISGR GASLGYSSAL IVQIVSMFLV ASKKGSKQDV QVAVLFVGIW
     251  WFVWQLPMIW LIDDVTIPIR VDDSTLASAR SPYPGEQDAL GQLNWKNYLS
     301  YGWVSLFESF KHARLLKDVM IFLIAWFIIS DSITTINSTA VLFSKAELHM
     351  STLNLIMISV LTVVNAMLGA FMIPQFLATK FRWTSSQTLM YIIIWASFIP
     401  FYGILGFFFN AFGLKHKFEM FLLAIWYGLS LGGLSAVSRS VFSLIVPPGK
     451  ESTFFSMFSI TDKGSSILGP FLVGLLTDKT HNIRYSFYFF FLLLMLSLPV
     501  LNCLDVKRGR REAEELSQVL PESERRLD*

external links for Atg22p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	TCDB
	DIP	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Atg22p

1)	Klionsky DJ, et al. (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5(4):539-45
2)	Harding TM, et al. (1996) Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway. J Biol Chem 271(30):17621-4
3)	Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74
4)	Suriapranata I, et al. (2000) The breakdown of autophagic vesicles inside the vacuole depends on Aut4p. J Cell Sci 113 ( Pt 22):4025-33
5)	Yang Z, et al. (2006) Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Mol Biol Cell 17(12):5094-104