GFD2/YCL036W Protein Information

Standard Name	Gfd2p
Systematic Name	Ycl036wp
Alias	Ycd6p 1
ORF Classification	Verified
Description	Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication (2, 3)
Name Description	Great for Full DEAD box protein activity 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	566
Molecular Weight (Da)	64,913
Isoelectric Point (pI)	8.76

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gfd2p (InterPro)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013A5D3 \| P25370 MIPS: YCL036W NCBI: 140369 \| 5327 \| 6319813 \| NP_009894.1 GenBank/EMBL/DDBJ: DAA07448.1 \| X59720

Amino Acid Sequence (or in FASTA format)
1 MQVQKMVRDN SNNGSDKSVH WERRNNNGAG PRYRSRSGNT GALATKLSNG 51 TLSVRGLVKD RTGSGKIAGC VEAFLDARTQ LNTPWDRAKC NWLDQIDYYV 101 QLRKTAFSKE LDQLRKPMID AYVAEMRQKF DASYGQSRAQ LEAKLAQVDS 151 EWHMVHGDVH AKLEKLVEER RFLKRLSDTI VPPRSKRSQR LSPLTKEDRA 201 NCICPQPKGM SDTAWFEAIQ KKMLGMNGTI KLLETEQKLL ADEKNSVRKT 251 FWPMVEAHSR SNEFAYLEKC IRLMASQRAI CFCLDIEAFE TNQNVITEIG 301 ISIYDPRENM VPSMVPITKN YHLIIEESLE LRNQKWVCDY KDCYLLGESY 351 VLSLKECVHF IQSLINYYLV PVTEEDKTWS RAFVGHHVSG DLKWLETIGV 401 KFPGRGYEGH LDHTLLLAET PGDLDVFILD TEQFYRKSYG EKGSSLGKIL 451 RLFEIPHAFL HNAGNDAYYT LHLFMKFCDV NFRKISGMDD VLKVMGQVKV 501 WGERDVREPK VVPMSYAISI EEAVKNRTYR KGVKSSRKER VCQTEFGGLT 551 YFGTAKDAFT STLPTH*

Amino Acid Sequence (or in FASTA format)

       1  MQVQKMVRDN SNNGSDKSVH WERRNNNGAG PRYRSRSGNT GALATKLSNG
      51  TLSVRGLVKD RTGSGKIAGC VEAFLDARTQ LNTPWDRAKC NWLDQIDYYV
     101  QLRKTAFSKE LDQLRKPMID AYVAEMRQKF DASYGQSRAQ LEAKLAQVDS
     151  EWHMVHGDVH AKLEKLVEER RFLKRLSDTI VPPRSKRSQR LSPLTKEDRA
     201  NCICPQPKGM SDTAWFEAIQ KKMLGMNGTI KLLETEQKLL ADEKNSVRKT
     251  FWPMVEAHSR SNEFAYLEKC IRLMASQRAI CFCLDIEAFE TNQNVITEIG
     301  ISIYDPRENM VPSMVPITKN YHLIIEESLE LRNQKWVCDY KDCYLLGESY
     351  VLSLKECVHF IQSLINYYLV PVTEEDKTWS RAFVGHHVSG DLKWLETIGV
     401  KFPGRGYEGH LDHTLLLAET PGDLDVFILD TEQFYRKSYG EKGSSLGKIL
     451  RLFEIPHAFL HNAGNDAYYT LHLFMKFCDV NFRKISGMDD VLKVMGQVKV
     501  WGERDVREPK VVPMSYAISI EEAVKNRTYR KGVKSSRKER VCQTEFGGLT
     551  YFGTAKDAFT STLPTH*

external links for Gfd2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Gfd2p

1)	Moser MJ, et al. (1997) The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains. Nucleic Acids Res 25(24):5110-8
2)	Estruch F and Cole CN (2003) An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components. Mol Biol Cell 14(4):1664-76
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61