HIS4/YCL030C Protein Information Help

Standard Name His4p 1, 2
Systematic Name Ycl030cp
ORF Classification Verified
Description Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis (3)
Name Description HIStidine requiring 2
Experimental Data
Molecules/cell 521 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 799
Molecular Weight (Da) 87,721
Isoelectric Point (pI) 5.04

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with His4p (InterPro)
Physical Interactions There are 18 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000000BF3 | P00815
MIPS: YCL030C
NCBI: 10383761 | 14588907 | 3783 | 3785 | 487421 | 487422 | 49065653 | 493494 | 493495 | 493496 | NP_009900.2 | NM_001178675.1
GenBank/EMBL/DDBJ: DAA07454.1 | M11491 | M11492 | M11694 | M11695 | M11696 | V01309 | V01310 | X59720
External Classifications EC: 1.1.1.23 [Histidinol dehydrogenase]
EC: 3.5.4.19 [Phosphoribosyl-AMP cyclohydrolase]
EC: 3.6.1.31 [Phosphoribosyl-ATP diphosphatase]
Amino Acid Sequence (or in FASTA format)
 
       1  MVLPILPLID DLASWNSKKE YVSLVGQVLL DGSSLSNEEI LQFSKEEEVP
      51  LVALSLPSGK FSDDEIIAFL NNGVSSLFIA SQDAKTAEHL VEQLNVPKER
     101  VVVEENGVFS NQFMVKQKFS QDKIVSIKKL SKDMLTKEVL GEVRTDRPDG
     151  LYTTLVVDQY ERCLGLVYSS KKSIAKAIDL GRGVYYSRSR NEIWIKGETS
     201  GNGQKLLQIS TDCDSDALKF IVEQENVGFC HLETMSCFGE FKHGLVGLES
     251  LLKQRLQDAP EESYTRRLFN DSALLDAKIK EEAEELTEAK GKKELSWEAA
     301  DLFYFALAKL VANDVSLKDV ENNLNMKHLK VTRRKGDAKP KFVGQPKAEE
     351  EKLTGPIHLD VVKASDKVGV QKALSRPIQK TSEIMHLVNP IIENVRDKGN
     401  SALLEYTEKF DGVKLSNPVL NAPFPEEYFE GLTEEMKEAL DLSIENVRKF
     451  HAAQLPTETL EVETQPGVLC SRFPRPIEKV GLYIPGGTAI LPSTALMLGV
     501  PAQVAQCKEI VFASPPRKSD GKVSPEVVYV AEKVGASKIV LAGGAQAVAA
     551  MAYGTETIPK VDKILGPGNQ FVTAAKMYVQ NDTQALCSID MPAGPSEVLV
     601  IADEDADVDF VASDLLSQAE HGIDSQVILV GVNLSEKKIQ EIQDAVHNQA
     651  LQLPRVDIVR KCIAHSTIVL CDGYEEALEM SNQYAPEHLI LQIANANDYV
     701  KLVDNAGSVF VGAYTPESCG DYSSGTNHTL PTYGYARQYS GANTATFQKF
     751  ITAQNITPEG LENIGRAVMC VAKKEGLDGH RNAVKIRMSK LGLIPKDFQ*

external links for His4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for His4p
1) Donahue TF, et al.  (1982) The nucleotide sequence of the HIS4 region of yeast. Gene 18(1):47-59
2) Shaffer B, et al.  (1969) Nonsense mutations affecting the his4 enzyme complex of yeast. Proc Natl Acad Sci U S A 63(4):1198-205
3) Keesey JK Jr, et al.  (1979) The product of the his4 gene cluster in Saccharomyces cerevisiae. A trifunctional polypeptide. J Biol Chem 254(15):7427-33
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41