AGP1/YCL025C Protein Information Help

Standard Name Agp1p
Systematic Name Ycl025cp
Alias Ycc5p
ORF Classification Verified
Description Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication (1, 2, 3)
Name Description high-Affinity Glutamine Permease 1
Experimental Data
Molecules/cell 21100 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 633
Molecular Weight (Da) 69,671
Isoelectric Point (pI) 6.95

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Agp1p (InterPro)
Transmembrane Domains There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 38 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00006842A3 | P25376
MIPS: YCL025C
NCBI: 14588912 | 187608879 | 45644967 | 85666113 | NP_009905.3
GenBank/EMBL/DDBJ: DAA07460.1 | X59720
External Classifications TC: 2.A.3.10 [The Yeast Amino Acid Transporter (YAT) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MSSSKSLYEL KDLKNSSTEI HATGQDNEIE YFETGSNDRP SSQPHLGYEQ
      51  HNTSAVRRFF DSFKRADQGP QDEVEATQMN DLTSAISPSS RQAQELEKNE
     101  SSDNIGANTG HKSDSLKKTI QPRHVLMIAL GTGIGTGLLV GNGTALVHAG
     151  PAGLLIGYAI MGSILYCIIQ ACGEMALVYS NLTGGYNAYP SFLVDDGFGF
     201  AVAWVYCLQW LCVCPLELVT ASMTIKYWTT SVNPDVFVII FYVLVITINI
     251  FGARGYAEAE FFFNCCKILM MTGFFILGII IDVGGAGNDG FIGGKYWHDP
     301  GAFNGKHAID RFKGVAATLV TAAFAFGGSE FIAITTAEQS NPRKAIPGAA
     351  KQMIYRILFL FLATIILLGF LVPYNSDQLL GSTGGGTKAS PYVIAVASHG
     401  VRVVPHFINA VILLSVLSMA NSSFYSSARL FLTLSEQGYA PKVFSYIDRA
     451  GRPLIAMGVS ALFAVIAFCA ASPKEEQVFT WLLAISGLSQ LFTWTAICLS
     501  HLRFRRAMKV QGRSLGELGF KSQTGVWGSA YACIMMILIL IAQFWVAIAP
     551  IGEGKLDAQA FFENYLAMPI LIALYVGYKV WHKDWKLFIR ADKIDLDSHR
     601  QIFDEELIKQ EDEEYRERLR NGPYWKRVVA FWC*

external links for Agp1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome TCDB
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Agp1p
1) Schreve JL, et al.  (1998) The Saccharomyces cerevisiae YCC5 (YCL025c) gene encodes an amino acid permease, Agp1, which transports asparagine and glutamine. J Bacteriol 180(9):2556-9
2) Forsberg H, et al.  (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41