LEU2/YCL018W Protein Information

Standard Name	Leu2p
Systematic Name	Ycl018wp
ORF Classification	Verified
Description	Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway (1)
Name Description	LEUcine biosynthesis 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	364
Molecular Weight (Da)	38,952
Isoelectric Point (pI)	5.55

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Leu2p (InterPro)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000000BF5 \| P04173 MIPS: YCL018W NCBI: 10383772 \| 14588917 \| 171839 \| 45644940 \| 4698 \| NP_009911.2 GenBank/EMBL/DDBJ: DAA07465.1 \| M12909 \| X03840 \| X59720
External Classifications	EC: 1.1.1.85 [3-isopropylmalate dehydrogenase]

Amino Acid Sequence (or in FASTA format)
1 MSAPKKIVVL PGDHVGQEIT AEAIKVLKAI SDVRSNVKFD FENHLIGGAA 51 IDATGVPLPD EALEASKKAD AVLLGAVGGP KWGTGSVRPE QGLLKIRKEL 101 QLYANLRPCN FASDSLLDLS PIKPQFAKGT DFVVVRELVG GIYFGKRKED 151 DGDGVAWDSE QYTVPEVQRI TRMAAFMALQ HEPPLPIWSL DKANVLASSR 201 LWRKTVEETI KNEFPTLKVQ HQLIDSAAMI LVKNPTHLNG IIITSNMFGD 251 IISDEASVIP GSLGLLPSAS LASLPDKNTA FGLYEPCHGS APDLPKNKVN 301 PIATILSAAM MLKLSLNLPE EGKAIEDAVK KVLDAGIRTG DLGGSNSTTE 351 VGDAVAEEVK KILA*

Amino Acid Sequence (or in FASTA format)

       1  MSAPKKIVVL PGDHVGQEIT AEAIKVLKAI SDVRSNVKFD FENHLIGGAA
      51  IDATGVPLPD EALEASKKAD AVLLGAVGGP KWGTGSVRPE QGLLKIRKEL
     101  QLYANLRPCN FASDSLLDLS PIKPQFAKGT DFVVVRELVG GIYFGKRKED
     151  DGDGVAWDSE QYTVPEVQRI TRMAAFMALQ HEPPLPIWSL DKANVLASSR
     201  LWRKTVEETI KNEFPTLKVQ HQLIDSAAMI LVKNPTHLNG IIITSNMFGD
     251  IISDEASVIP GSLGLLPSAS LASLPDKNTA FGLYEPCHGS APDLPKNKVN
     301  PIATILSAAM MLKLSLNLPE EGKAIEDAVK KVLDAGIRTG DLGGSNSTTE
     351  VGDAVAEEVK KILA*

external links for Leu2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Leu2p

1)	Andreadis A, et al. (1984) Yeast LEU2. Repression of mRNA levels by leucine and primary structure of the gene product. J Biol Chem 259(13):8059-62