DCC1/YCL016C Protein Information

Standard Name	Dcc1p
Systematic Name	Ycl016cp
ORF Classification	Verified
Description	Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance (1, 2)
Name Description	Defective in sister Chromatid Cohesion

Experimental Data
Molecules/cell	1660 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	380
Molecular Weight (Da)	44,073
Isoelectric Point (pI)	6.45

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Dcc1p (InterPro)
Physical Interactions	There are 8 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B3D0 \| P25559 MIPS: YCL016C NCBI: 10383774 \| 14588919 \| 32363494 \| NP_009913.2 GenBank/EMBL/DDBJ: DAA07467.1 \| X59720

Amino Acid Sequence (or in FASTA format)
1 MSINLHSAPE YDPSYKLIQL TPELLDIIQD PVQNHQLRFK SLDKDKSEVV 51 LCSHDKTWVL KQRKHSNTVL LMREFVPEQP ITFDETLLFG LSKPYMDVVG 101 FAKTESEFET RETHGELNLN SVPIYNGELD FSDKIMKRSS TKVIGTLEEL 151 LENSPCSALE GISKWHKIGG SVKDGVLCIL SQDFLFKALH VLLMSAMAES 201 LDLQHLNVED THHAVGKDIE DEFNPYTREI IETVLNKFAV QEQEAENNTW 251 RLRIPFIAQW YGIQALRKYV SGISMPIDEF LIKWKSLFPP FFPCDIDIDM 301 LRGYHFKPTD KTVQYIAKST LPMDPKERFK VLFRLQSQWD LEDIKPLIEE 351 LNSRGMKIDS FIMKYARRKR LGKKTVVTSR *

Amino Acid Sequence (or in FASTA format)

       1  MSINLHSAPE YDPSYKLIQL TPELLDIIQD PVQNHQLRFK SLDKDKSEVV
      51  LCSHDKTWVL KQRKHSNTVL LMREFVPEQP ITFDETLLFG LSKPYMDVVG
     101  FAKTESEFET RETHGELNLN SVPIYNGELD FSDKIMKRSS TKVIGTLEEL
     151  LENSPCSALE GISKWHKIGG SVKDGVLCIL SQDFLFKALH VLLMSAMAES
     201  LDLQHLNVED THHAVGKDIE DEFNPYTREI IETVLNKFAV QEQEAENNTW
     251  RLRIPFIAQW YGIQALRKYV SGISMPIDEF LIKWKSLFPP FFPCDIDIDM
     301  LRGYHFKPTD KTVQYIAKST LPMDPKERFK VLFRLQSQWD LEDIKPLIEE
     351  LNSRGMKIDS FIMKYARRKR LGKKTVVTSR *

external links for Dcc1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Dcc1p

1)	Mayer ML, et al. (2001) Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol Cell 7(5):959-70
2)	Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41