TSC10/YBR265W Protein Information

Standard Name	Tsc10p 1
Systematic Name	Ybr265wp
ORF Classification	Verified
Description	3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family (1)
Name Description	Temperature-sensitive Suppressors of Csg2 mutants 1

Experimental Data
Molecules/cell	7700 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	320
Molecular Weight (Da)	35,972
Isoelectric Point (pI)	6.25

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tsc10p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0001779DAC \| P38342 MIPS: YBR265W NCBI: 296564 \| 330443467 \| 342187083 \| 536696 \| 586382 \| NP_009824.2 \| NM_001178613.2 GenBank/EMBL/DDBJ: DAA07382.2 \| X70529 \| Z36134
External Classifications	EC: 1.1.1.102 [3-dehydrosphinganine reductase]

Amino Acid Sequence (or in FASTA format)
1 MKFTLEDQVV LITGGSQGLG KEFAKKYYNE AENTKIIIVS RSEARLLDTC 51 NEIRIEAHLR RETTDEGQVQ HKLAAPLDLE QRLFYYPCDL SCYESVECLF 101 NALRDLDLLP TQTLCCAGGA VPKLFRGLSG HELNLGMDIN YKTTLNVAHQ 151 IALAEQTKEH HLIIFSSATA LYPFVGYSQY APAKAAIKSL VAILRQELTN 201 FRISCVYPGN FESEGFTVEQ LTKPEITKLI EGPSDAIPCK QACDIIAKSL 251 ARGDDDVFTD FVGWMIMGMD LGLTAKKSRF VPLQWIFGVL SNILVVPFYM 301 VGCSWYIRKW FRENDGKKAN *

Amino Acid Sequence (or in FASTA format)

       1  MKFTLEDQVV LITGGSQGLG KEFAKKYYNE AENTKIIIVS RSEARLLDTC
      51  NEIRIEAHLR RETTDEGQVQ HKLAAPLDLE QRLFYYPCDL SCYESVECLF
     101  NALRDLDLLP TQTLCCAGGA VPKLFRGLSG HELNLGMDIN YKTTLNVAHQ
     151  IALAEQTKEH HLIIFSSATA LYPFVGYSQY APAKAAIKSL VAILRQELTN
     201  FRISCVYPGN FESEGFTVEQ LTKPEITKLI EGPSDAIPCK QACDIIAKSL
     251  ARGDDDVFTD FVGWMIMGMD LGLTAKKSRF VPLQWIFGVL SNILVVPFYM
     301  VGCSWYIRKW FRENDGKKAN *

external links for Tsc10p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Tsc10p

1)	Beeler T, et al. (1998) The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant. J Biol Chem 273(46):30688-94
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41