RGD1/YBR260C Protein Information

Standard Name	Rgd1p
Systematic Name	Ybr260cp
ORF Classification	Verified
Description	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization (1, 2)
Name Description	Related GAP Domain 1

Experimental Data
Molecules/cell	1500 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	666
Molecular Weight (Da)	74,618
Isoelectric Point (pI)	8.56

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rgd1p (InterPro)
Physical Interactions	There are 27 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000133815 \| P38339 MIPS: YBR260C NCBI: 1907248 \| 536687 \| 586378 \| 6319737 \| NP_009819.1 \| NM_001178608.1 GenBank/EMBL/DDBJ: DAA07377.1 \| X70529 \| Z36129

Amino Acid Sequence (or in FASTA format)
1 MEETAKKPAS ATVSAKSSHD GGTDDLAHLF STPEIKKVLN SDVAINALLS 51 RLKQSLLTCE EFMKFIRKKY AFEEEHVQEL SKQYKHFFNI QGSTNSSLKK 101 MIHEVLGFDG KMAQVKQSYI TALQKMYSEI SSLLLTMTKL RKSVKENSKR 151 LEKDVSDAIH SAEKAQSRYN SLCQDWDKLR MTDPTKTKLT LRGSKTTKEQ 201 EEELLRKIDN ADLEYKQKVD HSNSLRNTFI TKERPRIVQE LKDLILEIDT 251 AMTIQLQKYT IWTENLVLNT GVTISPLDST KSMKSFAGSV SNERDLYSFL 301 NKYNQTGKHS LLINKNLIPV SYKKHPSMNH GQKNKSPPKF AVDPSRNSIP 351 KRMISTHNES PFLSSSSNTA AVPNANLNSA TPSLNTNKQL PPTMASSISS 401 TSNAAGAMSP SSSIVTSDTT SSITKTLDPG NNSPQIPEEL INSLDSDRPI 451 SHIQTNNNMP PGVQKNFKTF GVPLESLIEF EQDMVPAIVR QCIYVIDKFG 501 LDQEGIYRKS ANVLDVSKLK EEIDKDPANI SMILPSKPHS DSDIYLVGSL 551 LKTFFASLPD SVLPKALSSE IKVCLQIEDP TTRKNFMHGL IYNLPDAQYW 601 TLRALVFHLK RVLAHEAQNR MNLRALCIIW GPTIAPANPD DANDVNFQIM 651 AMEVLLEVSD QAFEPE*

Amino Acid Sequence (or in FASTA format)

       1  MEETAKKPAS ATVSAKSSHD GGTDDLAHLF STPEIKKVLN SDVAINALLS
      51  RLKQSLLTCE EFMKFIRKKY AFEEEHVQEL SKQYKHFFNI QGSTNSSLKK
     101  MIHEVLGFDG KMAQVKQSYI TALQKMYSEI SSLLLTMTKL RKSVKENSKR
     151  LEKDVSDAIH SAEKAQSRYN SLCQDWDKLR MTDPTKTKLT LRGSKTTKEQ
     201  EEELLRKIDN ADLEYKQKVD HSNSLRNTFI TKERPRIVQE LKDLILEIDT
     251  AMTIQLQKYT IWTENLVLNT GVTISPLDST KSMKSFAGSV SNERDLYSFL
     301  NKYNQTGKHS LLINKNLIPV SYKKHPSMNH GQKNKSPPKF AVDPSRNSIP
     351  KRMISTHNES PFLSSSSNTA AVPNANLNSA TPSLNTNKQL PPTMASSISS
     401  TSNAAGAMSP SSSIVTSDTT SSITKTLDPG NNSPQIPEEL INSLDSDRPI
     451  SHIQTNNNMP PGVQKNFKTF GVPLESLIEF EQDMVPAIVR QCIYVIDKFG
     501  LDQEGIYRKS ANVLDVSKLK EEIDKDPANI SMILPSKPHS DSDIYLVGSL
     551  LKTFFASLPD SVLPKALSSE IKVCLQIEDP TTRKNFMHGL IYNLPDAQYW
     601  TLRALVFHLK RVLAHEAQNR MNLRALCIIW GPTIAPANPD DANDVNFQIM
     651  AMEVLLEVSD QAFEPE*

external links for Rgd1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Rgd1p

1)	Barthe C, et al. (1998) First characterization of the gene RGD1 in the yeast Saccharomyces cerevisiae. C R Acad Sci III 321(6):453-62
2)	Roumanie O, et al. (2000) Evidence for the genetic interaction between the actin-binding protein Vrp1 and the RhoGAP Rgd1 mediated through Rho3p and Rho4p in Saccharomyces cerevisiae. Mol Microbiol 36(6):1403-14
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41