MTC4/YBR255W Protein Information

Standard Name	Mtc4p 1
Systematic Name	Ybr255wp
ORF Classification	Verified
Description	Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 (1, 2, 3)
Name Description	Maintenance of Telomere Capping 1

Experimental Data
Molecules/cell	396 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	694
Molecular Weight (Da)	79,027
Isoelectric Point (pI)	10.49

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mtc4p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013A296 \| P38335 MIPS: YBR255W NCBI: 296554 \| 398365745 \| 536677 \| 586374 \| NP_009814.3 \| NM_001178603.3 GenBank/EMBL/DDBJ: DAA07371.1 \| X70529 \| Z36124

Amino Acid Sequence (or in FASTA format)
1 MTHTNEHDHK AEQQQNGRGD TTTETVNPQK MKLVTKLLID NKFGLMDDLN 51 FSIPLTASSE GVPISAKTSE LGTEYLKNQQ ENSVSPILPI SRSTRIKADR 101 VRIYLDYYYN ILERCISIDS SQNHHEGVEG VYNPLQVIRN RKLKKKHHEL 151 PTREFYTTKH PIIAIKQFSK KPNKKMPWFV DINEKYMDLT WRTSHWEELV 201 DPQGKLWFQS YSPSNESSGS SSSRRHHGHH IHPRRHLQHH SRVRTANSVH 251 SNTQSLTPKR VMTNEEDNNN HNNNNMITKI ATTPEAQISR NKKSDLNLSH 301 IHLEVPITNT VTNTSSDQGS LIIEAKGSSY GGDRRGSSNT SGSGGKRNSK 351 HYRSKSAGPP ENEKSRMNGL EKIISKTSKG WSRSPKKNTP GLEKQVLLNP 401 TISNGGTSRR SSNNGESIST NSSKSSMGIT FGNTETYKTP VDNGKDAIIR 451 QSLLSEVPVH TLRGKTSNRS LRAEGEQALE SDKELPNGAG SIYEGAPREK 501 TTSQGSEPVG LVSDSLQVDE QLQRYWHDTR YIMSTVAMMQ HRRETHDIVK 551 RREIARRNEI EITQDADTNI RKTADALTQY DNELNKVLKL GNDWTSKLLN 601 DYSIRVETLI SSSDRILSDI NTTLTLKLKM FQENTERYVT VKVMRAQKMT 651 KTIYRLLEFG IVLVLWTIWF LFSVLRSIRF TIFLVLKIIK ALLW*

Amino Acid Sequence (or in FASTA format)

       1  MTHTNEHDHK AEQQQNGRGD TTTETVNPQK MKLVTKLLID NKFGLMDDLN
      51  FSIPLTASSE GVPISAKTSE LGTEYLKNQQ ENSVSPILPI SRSTRIKADR
     101  VRIYLDYYYN ILERCISIDS SQNHHEGVEG VYNPLQVIRN RKLKKKHHEL
     151  PTREFYTTKH PIIAIKQFSK KPNKKMPWFV DINEKYMDLT WRTSHWEELV
     201  DPQGKLWFQS YSPSNESSGS SSSRRHHGHH IHPRRHLQHH SRVRTANSVH
     251  SNTQSLTPKR VMTNEEDNNN HNNNNMITKI ATTPEAQISR NKKSDLNLSH
     301  IHLEVPITNT VTNTSSDQGS LIIEAKGSSY GGDRRGSSNT SGSGGKRNSK
     351  HYRSKSAGPP ENEKSRMNGL EKIISKTSKG WSRSPKKNTP GLEKQVLLNP
     401  TISNGGTSRR SSNNGESIST NSSKSSMGIT FGNTETYKTP VDNGKDAIIR
     451  QSLLSEVPVH TLRGKTSNRS LRAEGEQALE SDKELPNGAG SIYEGAPREK
     501  TTSQGSEPVG LVSDSLQVDE QLQRYWHDTR YIMSTVAMMQ HRRETHDIVK
     551  RREIARRNEI EITQDADTNI RKTADALTQY DNELNKVLKL GNDWTSKLLN
     601  DYSIRVETLI SSSDRILSDI NTTLTLKLKM FQENTERYVT VKVMRAQKMT
     651  KTIYRLLEFG IVLVLWTIWF LFSVLRSIRF TIFLVLKIIK ALLW*

external links for Mtc4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Mtc4p

1)	Addinall SG, et al. (2008) A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae. Genetics 180(4):2251-66
2)	Sanjuan R, et al. (1999) Basic phenotypic analysis of six novel yeast genes reveals two essential genes and one which affects the growth rate. Yeast 15(4):351-60
3)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41