SRB6/YBR253W Protein Information Help

Standard Name Srb6p 1
Systematic Name Ybr253wp
Alias Med22p 2
ORF Classification Verified
Description Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation (1, 3, 4)
Name Description Suppressor of RNA polymerase B 1
Experimental Data
Molecules/cell 2180 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 121
Molecular Weight (Da) 13,863
Isoelectric Point (pI) 4.42

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Srb6p (InterPro)
Physical Interactions There are 149 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000005315E | P32570
MIPS: YBR253W
NCBI: 172695 | 296552 | 330689679 | 330689681 | 330689683 | 330689685 | 330689687 | 330689689 | 330689691 | 330689693 | 330689695 | 330689697 | 330689699 | 330689701 | 345100887 | 345100894 | 345100901 | 410563052 | 410563059 | 410563146 | 417808 | 459358309 | 536673 | 6319730 | NP_009812.1
GenBank/EMBL/DDBJ: DAA07369.1 | L12027 | X70529 | Z36122
Amino Acid Sequence (or in FASTA format)
 
       1  MSNQALYEKL EQTRTILSVK LAELINMTTI ADRNDDDEGS FAQENSELAV
      51  ATTSVMMVNN QTMQLIKNVQ DLLILTRSIK EKWLLNQIPV TEHSKVTRFD
     101  EKQIEELLDN CIETFVAEKT T*

external links for Srb6p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Srb6p
1) Thompson CM, et al.  (1993) A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell 73(7):1361-75
2) Bourbon HM, et al.  (2004) A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 14(5):553-7
3) Kornberg RD  (2005) Mediator and the mechanism of transcriptional activation. Trends Biochem Sci 30(5):235-9
4) Takagi Y, et al.  (2006) Head module control of mediator interactions. Mol Cell 23(3):355-64
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41