ENP1/YBR247C Protein Information

Standard Name	Enp1p 1
Systematic Name	Ybr247cp
Alias	Meg1p
ORF Classification	Verified
Description	Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus (2)
Name Description	Essential Nuclear Protein 1

Experimental Data
Molecules/cell	21600 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	483
Molecular Weight (Da)	55,136
Isoelectric Point (pI)	4.66

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Enp1p (InterPro)
Physical Interactions	There are 249 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052FD0 \| P38333 MIPS: YBR247C NCBI: 1255216 \| 398365715 \| 536661 \| 586372 \| NP_009806.3 GenBank/EMBL/DDBJ: DAA07363.1 \| U50779 \| Z36116

Amino Acid Sequence (or in FASTA format)
1 MARASSTKAR KQRHDPLLKD LDAAQGTLKK INKKKLAQND AANHDAANEE 51 DGYIDSKASR KILQLAKEQQ DEIEGEELAE SERNKQFEAR FTTMSYDDED 101 EDEDEDEEAF GEDISDFEPE GDYKEEEEIV EIDEEDAAMF EQYFKKSDDF 151 NSLSGSYNLA DKIMASIREK ESQVEDMQDD EPLANEQNTS RGNISSGLKS 201 GEGVALPEKV IKAYTTVGSI LKTWTHGKLP KLFKVIPSLR NWQDVIYVTN 251 PEEWSPHVVY EATKLFVSNL TAKESQKFIN LILLERFRDN IETSEDHSLN 301 YHIYRAVKKS LYKPSAFFKG FLFPLVETGC NVREATIAGS VLAKVSVPAL 351 HSSAALSYLL RLPFSPPTTV FIKILLDKKY ALPYQTVDDC VYYFMRFRIL 401 DDGSNGEDAT RVLPVIWHKA FLTFAQRYKN DITQDQRDFL LETVRQRGHK 451 DIGPEIRREL LAGASREFVD PQEANDDLMI DVN*

Amino Acid Sequence (or in FASTA format)

       1  MARASSTKAR KQRHDPLLKD LDAAQGTLKK INKKKLAQND AANHDAANEE
      51  DGYIDSKASR KILQLAKEQQ DEIEGEELAE SERNKQFEAR FTTMSYDDED
     101  EDEDEDEEAF GEDISDFEPE GDYKEEEEIV EIDEEDAAMF EQYFKKSDDF
     151  NSLSGSYNLA DKIMASIREK ESQVEDMQDD EPLANEQNTS RGNISSGLKS
     201  GEGVALPEKV IKAYTTVGSI LKTWTHGKLP KLFKVIPSLR NWQDVIYVTN
     251  PEEWSPHVVY EATKLFVSNL TAKESQKFIN LILLERFRDN IETSEDHSLN
     301  YHIYRAVKKS LYKPSAFFKG FLFPLVETGC NVREATIAGS VLAKVSVPAL
     351  HSSAALSYLL RLPFSPPTTV FIKILLDKKY ALPYQTVDDC VYYFMRFRIL
     401  DDGSNGEDAT RVLPVIWHKA FLTFAQRYKN DITQDQRDFL LETVRQRGHK
     451  DIGPEIRREL LAGASREFVD PQEANDDLMI DVN*

external links for Enp1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Enp1p

1)	Roos J, et al. (1997) ENP1, an essential gene encoding a nuclear protein that is highly conserved from yeast to humans. Gene 185(1):137-46
2)	Chen W, et al. (2003) Enp1, a yeast protein associated with U3 and U14 snoRNAs, is required for pre-rRNA processing and 40S subunit synthesis. Nucleic Acids Res 31(2):690-9
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41