GPX2/YBR244W Protein Information Help

Standard Name Gpx2p 1
Systematic Name Ybr244wp
Alias Ami1p
ORF Classification Verified
Description Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description Glutathione PeroXidase 1
Experimental Data
Molecules/cell 2010 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 162
Molecular Weight (Da) 18,406
Isoelectric Point (pI) 8.82

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Gpx2p (InterPro)
Physical Interactions There are 12 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012BBF6 | P38143
MIPS: YBR244W
NCBI: 398365707 | 45269175 | 536655 | 585222 | NP_009803.3
GenBank/EMBL/DDBJ: DAA07360.1 | AY557641 | Z36113
External Classifications EC: 1.11.1.9 [Glutathione peroxidase]
Amino Acid Sequence (or in FASTA format)
 
       1  MTTSFYDLEC KDKKGESFKF DQLKGKVVLI VNVASKCGFT PQYKELEELY
      51  KKYQDKGFVI LGFPCNQFGK QEPGSDEQIT EFCQLNYGVT FPIMKKIDVN
     101  GSNADSVYNY LKSQKAGLLG FKGIKWNFEK FLVDSNGKVV QRFSSLTKPS
     151  SLDQEIQSLL SK*

external links for Gpx2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
YGOB CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Gpx2p
1) Inoue Y, et al.  (1999) Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae. J Biol Chem 274(38):27002-9
2) Avery AM and Avery SV  (2001) Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. J Biol Chem 276(36):33730-5
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41