KTR3/YBR205W Protein Information

Standard Name	Ktr3p 1
Systematic Name	Ybr205wp
ORF Classification	Verified
Description	Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress (2, 3, 4)
Name Description	Kre Two Related 5

Experimental Data
Molecules/cell	704 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	404
Molecular Weight (Da)	47,482
Isoelectric Point (pI)	9.15

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ktr3p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 28 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F2A \| P38130 MIPS: YBR205W NCBI: 311682 \| 398365497 \| 51013873 \| 536583 \| 585376 \| NP_009764.3 GenBank/EMBL/DDBJ: DAA07323.1 \| AY693211 \| Z21487 \| Z36074
External Classifications	EC: 2.4.1.- [Hexosyltransferases] EC: 2.4.1.131 [GDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase]

Amino Acid Sequence (or in FASTA format)
1 MSVHHKKKLM PKSALLIRKY QKGIRSSFIG LIIVLSFLFF MSGSRSPEVP 51 IAQGTSVSRV ASKDYLMPFT DKSQGVIHPV DDGKKEKGVM VTLARNSDLW 101 NLVKSIRHVE DRFNNRYHYD WVFLNDQPFS DEFKRVTSAL VSGKAKYGTI 151 PKDHWSIPSW IDTEKFDEKR LAMGKLDIPY GSSVPYRHMC RFQSGFIWRH 201 PLLEEYEWFW RVDTDITLFC DIQYDIFKFL KVNNKKYGFI LSVSEYERTI 251 PTLWETTKKF IKKNPKFLHK NNLMKFISND DGDTYNMCHF WTNFEIGSLD 301 FFRSDAYREY FDYLDSSGGF FYERWGDAPV HSIAASLFLD KSEIHFFDGL 351 GFHHPDFTSC PIEQKIRLQN KCICEPSKDV TWTPDYFCTR KYFSAGNYKL 401 PPGI*

Amino Acid Sequence (or in FASTA format)

       1  MSVHHKKKLM PKSALLIRKY QKGIRSSFIG LIIVLSFLFF MSGSRSPEVP
      51  IAQGTSVSRV ASKDYLMPFT DKSQGVIHPV DDGKKEKGVM VTLARNSDLW
     101  NLVKSIRHVE DRFNNRYHYD WVFLNDQPFS DEFKRVTSAL VSGKAKYGTI
     151  PKDHWSIPSW IDTEKFDEKR LAMGKLDIPY GSSVPYRHMC RFQSGFIWRH
     201  PLLEEYEWFW RVDTDITLFC DIQYDIFKFL KVNNKKYGFI LSVSEYERTI
     251  PTLWETTKKF IKKNPKFLHK NNLMKFISND DGDTYNMCHF WTNFEIGSLD
     301  FFRSDAYREY FDYLDSSGGF FYERWGDAPV HSIAASLFLD KSEIHFFDGL
     351  GFHHPDFTSC PIEQKIRLQN KCICEPSKDV TWTPDYFCTR KYFSAGNYKL
     401  PPGI*

external links for Ktr3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Ktr3p

1)	Bussereau F, et al. (1993) A 12.8 kb segment, on the right arm of chromosome II from Saccharomyces cerevisiae including part of the DUR1,2 gene, contains five putative new genes. Yeast 9(7):797-806
2)	Lussier M, et al. (1996) Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family. J Biol Chem 271(18):11001-8
3)	Bue CA and Barlowe C (2009) Molecular dissection of Erv26p identifies separable cargo binding and coat protein sorting activities. J Biol Chem 284(36):24049-60
4)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5)	Lussier M, et al. (1997) Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism. Yeast 13(3):267-74
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41