LDH1/YBR204C Protein Information

Standard Name	Ldh1p 1
Systematic Name	Ybr204cp
ORF Classification	Verified
Description	Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif) (2, 3, 4)
Name Description	Lipid Droplet Hydrolase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	375
Molecular Weight (Da)	43,287
Isoelectric Point (pI)	6.51

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ldh1p (InterPro)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000158D80C \| P38139 MIPS: YBR204C NCBI: 311681 \| 330443463 \| 341940895 \| 536581 \| 586328 \| NP_009763.2 GenBank/EMBL/DDBJ: DAA07322.2 \| Z21487 \| Z36073
External Classifications	EC: 3.1.1.- [Carboxylic ester hydrolases]

Amino Acid Sequence (or in FASTA format)
1 MNMAERAEAT KSWSCEPLSG KTLEEIVQNA ENAADLVAYI RKPEVDLDFR 51 LKFIAEHEEF FNVQLSDRNS RIRTCHNLSD KGIRGDTVFV FVPGLAGNLE 101 QFEPLLELVD SDQKAFLTLD LPGFGHSSEW SDYPMLKVVE LIFVLVCDVL 151 RKWSTAVPNN DNVNPFNGHK IVLVGHSMGC FLACHLYEQH MADTKAVQTL 201 VLLTPPKAHI EQLSKDKHII QWALYGVFKL PWLFDVYRNK FDQVKGLQSS 251 GIKQYFYQQG DDVKLKYRKF WQFKNNISNK SRTIIGYLLG WETVDWVKFN 301 GVLTQTDMKQ KIIIFGAEKD PIAPIENLEF YKQTINKECL RKVIILPDCS 351 HNLCFDRPEL VCENFQREVI DNSKL*

Amino Acid Sequence (or in FASTA format)

       1  MNMAERAEAT KSWSCEPLSG KTLEEIVQNA ENAADLVAYI RKPEVDLDFR
      51  LKFIAEHEEF FNVQLSDRNS RIRTCHNLSD KGIRGDTVFV FVPGLAGNLE
     101  QFEPLLELVD SDQKAFLTLD LPGFGHSSEW SDYPMLKVVE LIFVLVCDVL
     151  RKWSTAVPNN DNVNPFNGHK IVLVGHSMGC FLACHLYEQH MADTKAVQTL
     201  VLLTPPKAHI EQLSKDKHII QWALYGVFKL PWLFDVYRNK FDQVKGLQSS
     251  GIKQYFYQQG DDVKLKYRKF WQFKNNISNK SRTIIGYLLG WETVDWVKFN
     301  GVLTQTDMKQ KIIIFGAEKD PIAPIENLEF YKQTINKECL RKVIILPDCS
     351  HNLCFDRPEL VCENFQREVI DNSKL*

external links for Ldh1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ldh1p

1)	Thoms S, et al. (2011) The putative Saccharomyces cerevisiae hydrolase Ldh1p is localized to lipid droplets. Eukaryot Cell 10(6):770-5
2)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3)	Baxter SM, et al. (2004) Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast. Mol Cell Proteomics 3(3):209-25
4)	Debelyy MO, et al. (2011) Involvement of the Saccharomyces cerevisiae hydrolase Ldh1p in lipid homeostasis. Eukaryot Cell 10(6):776-81