LDH1/YBR204C Protein Information Help

Standard Name Ldh1p 1
Systematic Name Ybr204cp
ORF Classification Verified
Description Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif) (2, 3, 4)
Name Description Lipid Droplet Hydrolase 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 375
Molecular Weight (Da) 43,287
Isoelectric Point (pI) 6.51

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ldh1p (InterPro)
Physical Interactions There are 2 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000158D80C | P38139
MIPS: YBR204C
NCBI: 311681 | 330443463 | 341940895 | 536581 | 586328 | NP_009763.2 | NM_001178552.2
GenBank/EMBL/DDBJ: CAA79692.1 | CAA85168.1 | DAA07322.2 | Z21487 | Z36073
External Classifications EC: 3.1.1.- [Carboxylic ester hydrolases]
EC: 3.1.1.3 [Triacylglycerol lipase]
Amino Acid Sequence (or in FASTA format)
       1  MNMAERAEAT KSWSCEPLSG KTLEEIVQNA ENAADLVAYI RKPEVDLDFR
      51  LKFIAEHEEF FNVQLSDRNS RIRTCHNLSD KGIRGDTVFV FVPGLAGNLE
     101  QFEPLLELVD SDQKAFLTLD LPGFGHSSEW SDYPMLKVVE LIFVLVCDVL
     151  RKWSTAVPNN DNVNPFNGHK IVLVGHSMGC FLACHLYEQH MADTKAVQTL
     201  VLLTPPKAHI EQLSKDKHII QWALYGVFKL PWLFDVYRNK FDQVKGLQSS
     251  GIKQYFYQQG DDVKLKYRKF WQFKNNISNK SRTIIGYLLG WETVDWVKFN
     301  GVLTQTDMKQ KIIIFGAEKD PIAPIENLEF YKQTINKECL RKVIILPDCS
     351  HNLCFDRPEL VCENFQREVI DNSKL*                          

external links for Ldh1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Ldh1p
1) Thoms S, et al.  (2011) The putative Saccharomyces cerevisiae hydrolase Ldh1p is localized to lipid droplets. Eukaryot Cell 10(6):770-5
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Baxter SM, et al.  (2004) Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast. Mol Cell Proteomics 3(3):209-25
4) Debelyy MO, et al.  (2011) Involvement of the Saccharomyces cerevisiae hydrolase Ldh1p in lipid homeostasis. Eukaryot Cell 10(6):776-81