MCM7/YBR202W Protein Information

Standard Name	Mcm7p 1
Systematic Name	Ybr202wp
Alias	Cdc47p 2
ORF Classification	Verified
Description	Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex (3, 4)
Name Description	MiniChromosome Maintenance 1

Experimental Data
Molecules/cell	166 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	845
Molecular Weight (Da)	94,943
Isoelectric Point (pI)	4.91

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mcm7p (InterPro)
Physical Interactions	There are 94 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012724E \| P38132 MIPS: YBR202W NCBI: 311678 \| 341941141 \| 398365471 \| 536577 \| 55977791 \| 608169 \| NP_009761.4 GenBank/EMBL/DDBJ: DAA07320.2 \| U14730 \| Z21487 \| Z36071
External Classifications	EC: 3.6.4.12 [DNA helicase]

Amino Acid Sequence (or in FASTA format)
1 MSAALPSIQL PVDYNNLFNE ITDFLVTFKQ DTLSSDATRN ENEDENLDAE 51 NIEQHLLEKG PKYMAMLQKV ANRELNSVII DLDDILQYQN EKFLQGTQAD 101 DLVSAIQQNA NHFTELFCRA IDNNMPLPTK EIDYKDDVLD VILNQRRLRN 151 ERMLSDRTNE IRSENLMDTT MDPPSSMNDA LREVVEDETE LFPPNLTRRY 201 FLYFKPLSQN CARRYRKKAI SSKPLSVRQI KGDFLGQLIT VRGIITRVSD 251 VKPAVEVIAY TCDQCGYEVF QEVNSRTFTP LSECTSEECS QNQTKGQLFM 301 STRASKFSAF QECKIQELSQ QVPVGHIPRS LNIHVNGTLV RSLSPGDIVD 351 VTGIFLPAPY TGFKALKAGL LTETYLEAQF VRQHKKKFAS FSLTSDVEER 401 VMELITSGDV YNRLAKSIAP EIYGNLDVKK ALLLLLVGGV DKRVGDGMKI 451 RGDINVCLMG DPGVAKSQLL KAICKISPRG VYTTGKGSSG VGLTAAVMKD 501 PVTDEMILEG GALVLADNGI CCIDEFDKMD ESDRTAIHEV MEQQTISISK 551 AGINTTLNAR TSILAAANPL YGRYNPRLSP LDNINLPAAL LSRFDILFLM 601 LDIPSRDDDE KLAEHVTYVH MHNKQPDLDF TPVEPSKMRE YIAYAKTKRP 651 VMSEAVNDYV VQAYIRLRQD SKREMDSKFS FGQATPRTLL GIIRLSQALA 701 KLRLADMVDI DDVEEALRLV RVSKESLYQE TNKSKEDESP TTKIFTIIKK 751 MLQETGKNTL SYENIVKTVR LRGFTMLQLS NCIQEYSYLN VWHLINEGNT 801 LKFVDDGTMD TDQEDSLVST PKLAPQTTAS ANVSAQDSDI DLQDA*

Amino Acid Sequence (or in FASTA format)

       1  MSAALPSIQL PVDYNNLFNE ITDFLVTFKQ DTLSSDATRN ENEDENLDAE
      51  NIEQHLLEKG PKYMAMLQKV ANRELNSVII DLDDILQYQN EKFLQGTQAD
     101  DLVSAIQQNA NHFTELFCRA IDNNMPLPTK EIDYKDDVLD VILNQRRLRN
     151  ERMLSDRTNE IRSENLMDTT MDPPSSMNDA LREVVEDETE LFPPNLTRRY
     201  FLYFKPLSQN CARRYRKKAI SSKPLSVRQI KGDFLGQLIT VRGIITRVSD
     251  VKPAVEVIAY TCDQCGYEVF QEVNSRTFTP LSECTSEECS QNQTKGQLFM
     301  STRASKFSAF QECKIQELSQ QVPVGHIPRS LNIHVNGTLV RSLSPGDIVD
     351  VTGIFLPAPY TGFKALKAGL LTETYLEAQF VRQHKKKFAS FSLTSDVEER
     401  VMELITSGDV YNRLAKSIAP EIYGNLDVKK ALLLLLVGGV DKRVGDGMKI
     451  RGDINVCLMG DPGVAKSQLL KAICKISPRG VYTTGKGSSG VGLTAAVMKD
     501  PVTDEMILEG GALVLADNGI CCIDEFDKMD ESDRTAIHEV MEQQTISISK
     551  AGINTTLNAR TSILAAANPL YGRYNPRLSP LDNINLPAAL LSRFDILFLM
     601  LDIPSRDDDE KLAEHVTYVH MHNKQPDLDF TPVEPSKMRE YIAYAKTKRP
     651  VMSEAVNDYV VQAYIRLRQD SKREMDSKFS FGQATPRTLL GIIRLSQALA
     701  KLRLADMVDI DDVEEALRLV RVSKESLYQE TNKSKEDESP TTKIFTIIKK
     751  MLQETGKNTL SYENIVKTVR LRGFTMLQLS NCIQEYSYLN VWHLINEGNT
     801  LKFVDDGTMD TDQEDSLVST PKLAPQTTAS ANVSAQDSDI DLQDA*

external links for Mcm7p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Mcm7p

1)	Kearsey SE, et al. (1996) Cell cycle control of eukaryotic DNA replication. Curr Opin Genet Dev 6(2):208-14
2)	Moir D, et al. (1982) Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics 100(4):547-63
3)	Tye BK (1999) MCM proteins in DNA replication. Annu Rev Biochem 68:649-86
4)	Ma X, et al. (2010) The effects of oligomerization on Saccharomyces cerevisiae Mcm4/6/7 function. BMC Biochem 11():37
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41