MCM7/YBR202W Protein Information Help

Standard Name Mcm7p 1
Systematic Name Ybr202wp
Alias Cdc47p 2
ORF Classification Verified
Description Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex (3, 4, 5)
Name Description MiniChromosome Maintenance 1
Experimental Data
Molecules/cell 166 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 845
Molecular Weight (Da) 94,943
Isoelectric Point (pI) 4.91

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mcm7p (InterPro)
Physical Interactions There are 95 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012724E | P38132
MIPS: YBR202W
NCBI: 311678 | 341941141 | 398365471 | 536577 | 55977791 | 608169 | NP_009761.4 | NM_001178550.4
GenBank/EMBL/DDBJ: AAA86309.1 | CAA79689.1 | CAA85166.1 | DAA07320.2 | U14730 | Z21487 | Z36071
External Classifications EC: 3.6.4.12 [DNA helicase]
Amino Acid Sequence (or in FASTA format)
       1  MSAALPSIQL PVDYNNLFNE ITDFLVTFKQ DTLSSDATRN ENEDENLDAE
      51  NIEQHLLEKG PKYMAMLQKV ANRELNSVII DLDDILQYQN EKFLQGTQAD
     101  DLVSAIQQNA NHFTELFCRA IDNNMPLPTK EIDYKDDVLD VILNQRRLRN
     151  ERMLSDRTNE IRSENLMDTT MDPPSSMNDA LREVVEDETE LFPPNLTRRY
     201  FLYFKPLSQN CARRYRKKAI SSKPLSVRQI KGDFLGQLIT VRGIITRVSD
     251  VKPAVEVIAY TCDQCGYEVF QEVNSRTFTP LSECTSEECS QNQTKGQLFM
     301  STRASKFSAF QECKIQELSQ QVPVGHIPRS LNIHVNGTLV RSLSPGDIVD
     351  VTGIFLPAPY TGFKALKAGL LTETYLEAQF VRQHKKKFAS FSLTSDVEER
     401  VMELITSGDV YNRLAKSIAP EIYGNLDVKK ALLLLLVGGV DKRVGDGMKI
     451  RGDINVCLMG DPGVAKSQLL KAICKISPRG VYTTGKGSSG VGLTAAVMKD
     501  PVTDEMILEG GALVLADNGI CCIDEFDKMD ESDRTAIHEV MEQQTISISK
     551  AGINTTLNAR TSILAAANPL YGRYNPRLSP LDNINLPAAL LSRFDILFLM
     601  LDIPSRDDDE KLAEHVTYVH MHNKQPDLDF TPVEPSKMRE YIAYAKTKRP
     651  VMSEAVNDYV VQAYIRLRQD SKREMDSKFS FGQATPRTLL GIIRLSQALA
     701  KLRLADMVDI DDVEEALRLV RVSKESLYQE TNKSKEDESP TTKIFTIIKK
     751  MLQETGKNTL SYENIVKTVR LRGFTMLQLS NCIQEYSYLN VWHLINEGNT
     801  LKFVDDGTMD TDQEDSLVST PKLAPQTTAS ANVSAQDSDI DLQDA*    

external links for Mcm7p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains YeastRC Public Image Repository
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Mcm7p
1) Kearsey SE, et al.  (1996) Cell cycle control of eukaryotic DNA replication. Curr Opin Genet Dev 6(2):208-14
2) Moir D, et al.  (1982) Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics 100(4):547-63
3) Tye BK  (1999) MCM proteins in DNA replication. Annu Rev Biochem 68:649-86
4) Ma X, et al.  (2010) The effects of oligomerization on Saccharomyces cerevisiae Mcm4/6/7 function. BMC Biochem 11():37
5) Bochman ML and Schwacha A  (2008) The Mcm2-7 complex has in vitro helicase activity. Mol Cell 31(2):287-93
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41