DER1/YBR201W Protein Information

Standard Name	Der1p 1
Systematic Name	Ybr201wp
ORF Classification	Verified
Description	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p (1, 2, 3)
Name Description	Degradation in the Endoplasmic Reticulum 1

Experimental Data
Molecules/cell	238 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	211
Molecular Weight (Da)	24,391
Isoelectric Point (pI)	8.35

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Der1p (InterPro)
Transmembrane Domains	There are 4 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 28 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001682C4 \| P38307 MIPS: YBR201W NCBI: 1044925 \| 1352236 \| 308153606 \| 311677 \| 4388575 \| 4388577 \| 6319678 \| NP_009760.1 GenBank/EMBL/DDBJ: DAA07318.1 \| X92435 \| Z21487 \| Z36069 \| Z36070

Amino Acid Sequence (or in FASTA format)
1 MDAVILNLLG DIPLVTRLWT IGCLVLSGLT SLRIVDPGKV VYSYDLVFKK 51 GQYGRLLYSI FDYGAFNWIS MINIFVSANH LSTLENSFNL RRKFCWIIFL 101 LLVILVKMTS IEQPAASLGV LLHENLVYYE LKKNGNQMNV RFFGAIDVSP 151 SIFPIYMNAV MYFVYKRSWL EIAMNFMPGH VIYYMDDIIG KIYGIDLCKS 201 PYDWFRNTET P*

Amino Acid Sequence (or in FASTA format)

       1  MDAVILNLLG DIPLVTRLWT IGCLVLSGLT SLRIVDPGKV VYSYDLVFKK
      51  GQYGRLLYSI FDYGAFNWIS MINIFVSANH LSTLENSFNL RRKFCWIIFL
     101  LLVILVKMTS IEQPAASLGV LLHENLVYYE LKKNGNQMNV RFFGAIDVSP
     151  SIFPIYMNAV MYFVYKRSWL EIAMNFMPGH VIYYMDDIIG KIYGIDLCKS
     201  PYDWFRNTET P*

external links for Der1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Der1p

1)	Knop M, et al. (1996) Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. EMBO J 15(4):753-63
2)	Sommer T and Wolf DH (1997) Endoplasmic reticulum degradation: reverse protein flow of no return. FASEB J 11(14):1227-33
3)	Hitt R and Wolf DH (2004) Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins. FEMS Yeast Res 4(7):721-9
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41