GDT1/YBR187W Protein Information Help

Standard Name Gdt1p 1
Systematic Name Ybr187wp
ORF Classification Verified
Description Protein of unknown function involved in calcium homeostasis; localizes to the cis- and medial-Golgi apparatus; GFP-fusion protein localizes to the vacuole; TMEM165, a human gene which causes Congenital Disorders of Glycosylation is orthologous and functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression reduced in a gcr1 null mutant (1, 2, 3)
Name Description Gcr1 Dependent Translation factor 1
Experimental Data
Molecules/cell 2170 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 280
Molecular Weight (Da) 30,340
Isoelectric Point (pI) 5.21

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Gdt1p (InterPro)
Transmembrane Domains There are 5 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 15 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013A20B | P38301
MIPS: YBR187W
NCBI: 1870114 | 45271024 | 536548 | 575915 | 586318 | 6319664 | NP_009746.1 | NM_001178535.1
GenBank/EMBL/DDBJ: AAB60282.1 | AAS56893.1 | CAA85148.1 | CAA85150.1 | DAA07302.1 | AY558567 | U02073 | Z36056 | Z36057
Amino Acid Sequence (or in FASTA format)
       1  MGNMIKKASL IALLPLFTAA AAAATDAETS MESGSSSHLK SFLMSVSMIG
      51  LSEIGDKTFL IAALMAMRHK RVLVFSAAAT SLAIMTILSG VVGHSAVAFL
     101  SERYTAFFAG ILFLVFGYKL TMEGLEMSKD AGVEEEMAEV EEEIAIKDMN
     151  QDMDDVEKGG DTAYDKQLKN ASIGKKIVHR IRELASFMFS PVWVQIFLMV
     201  FLGELGDRSQ ISIIAMATDS DYWYVIAGAV IGHAICSGLA VVGGKLLATR
     251  ISIRTITLAS SLLFFIFALM YIYQAFTTQD *                    

external links for Gdt1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) CYC2008 (complexes) MIPS YeastGFP
Candida (CGD) Complexome Pfam domains YeastRC Public Image Repository
YGOB DIP YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Gdt1p
1) Barbara KE, et al.  (2007) The transcription factor Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression on a global level. Mol Genet Genomics 277(2):171-88
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Demaegd D, et al.  (2013) Newly characterized Golgi-localized family of proteins is involved in calcium and pH homeostasis in yeast and human cells. Proc Natl Acad Sci U S A 110(17):6859-64
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41