PCH2/YBR186W Protein Information Help

Standard Name Pch2p 1
Systematic Name Ybr186wp
ORF Classification Verified
Description Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation (1, 2, 3, 4)
Name Description Pachytene CHeckpoint 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 564
Molecular Weight (Da) 63,460
Isoelectric Point (pI) 5.76

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pch2p (InterPro)
Physical Interactions There are 8 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001682C2 | P38126
MIPS: YBR186W
NCBI: 114152857 | 536546 | 575913 | 586317 | 9755327 | NP_009745.2 | NM_001178534.1
GenBank/EMBL/DDBJ: AAB60280.1 | CAA85147.1 | DAA07301.1 | U02073 | Z36055
Amino Acid Sequence (or in FASTA format)
       1  MSYIVDLQVR GSSLRVIKCM FREDEQISSL HSGSDSKQNS NKKLGEFLNL
      51  LKAVVKRKLE SFPKDRLKTS IITGQELMRE GQGSIEIKDP PTEAQQHLIR
     101  SLAKVLLHQF SSINGKVNTV NEGQDNLFLS LFVKKISIEQ QSTSHVSIKL
     151  NFHEKINLGQ HIDSILDSEE TNESDTYHMG SVDEFIIYPF CCLEEQDELK
     201  NGSILSTEFD KIDLELDEDD GFEGETLNNC INSVGNFDIP LSKQTLNLVN
     251  ISYLPGTTFE GQWESLYFGN NIKERLYSYA TISLKIARFK QTGDSNQEDI
     301  TTLITNNKLL LVHGPPGTGK TTLCKALCQK LSVRREFSDG SDTIDTNYKG
     351  IIIELSCARI FSKWFGESSK NISIVFKDIE ELLKVNEGRG IFICLLIDEV
     401  EAIASSRTNL SSRNESTDGI RVVNTLLTQL DRLKKYHNFL ALATSNLLDS
     451  LDDAFVDRAD GVFYVGNPTA EGILHILKVC IEEMITSGII LFHARSTGVK
     501  FFNKYQDILR KIAIKCSTVD ISGRTIRKLP LMCLSEYFRT FPVDDDEFVL
     551  ALAMSARKLS AARK*                                      

external links for Pch2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB CYC2008 (complexes) MIPS YeastGFP
YOGY Complexome Pfam domains

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Pch2p
1) San-Segundo PA and Roeder GS  (1999) Pch2 links chromatin silencing to meiotic checkpoint control. Cell 97(3):313-24
2) San-Segundo PA and Roeder GS  (2000) Role for the silencing protein Dot1 in meiotic checkpoint control. Mol Biol Cell 11(10):3601-15
3) Farmer S, et al.  (2012) Budding yeast pch2, a widely conserved meiotic protein, is involved in the initiation of meiotic recombination. PLoS One 7(6):e39724
4) Chen C, et al.  (2014) Pch2 is a hexameric ring ATPase that remodels the chromosome axis protein Hop1. Proc Natl Acad Sci U S A 111(1):E44-53