SWD3/YBR175W Protein Information

Standard Name	Swd3p 1
Systematic Name	Ybr175wp
Alias	Cps30p 2 , Saf35p 3
ORF Classification	Verified
Description	Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 (1, 2, 3, 4, 5, 6)
Name Description	Set1c, WD40 repeat protein

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	315
Molecular Weight (Da)	34,753
Isoelectric Point (pI)	5.93

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Swd3p (InterPro)
Physical Interactions	There are 70 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052FF2 \| P38123 MIPS: YBR175W NCBI: 51013875 \| 536523 \| 586308 \| 6319651 \| NP_009734.1 GenBank/EMBL/DDBJ: DAA07290.1 \| AY693212 \| Z36043

Amino Acid Sequence (or in FASTA format)
1 MFQFVTPVGT QNGLKATCAK ISPDGQFLAI TQGLNILIYD INRRTVSQTL 51 VTSHARPFSE LCWSPDGQCI ATASDDFSVE IIHLSYGLLH TFIGHTAPVI 101 SLTFNRKGNL LFTSSMDESI KIWDTLNGSL MKTISAHSEA VVSVDVPMND 151 SSILSSGSYD GLIRIFDAET GHCLKTLTYD KDWKRENGVV PISQVKFSEN 201 ARYLLVKSLD GVVKIWDCIG GCVVRTFQVQ PLEKGVLHHS CGMDFLNPED 251 GSTPLVISGY ENGDIYCWNS DTKSLLQLLD GSLYHHSSPV MSIHCFGNIM 301 CSLALNGDCC LWRWV*

Amino Acid Sequence (or in FASTA format)

       1  MFQFVTPVGT QNGLKATCAK ISPDGQFLAI TQGLNILIYD INRRTVSQTL
      51  VTSHARPFSE LCWSPDGQCI ATASDDFSVE IIHLSYGLLH TFIGHTAPVI
     101  SLTFNRKGNL LFTSSMDESI KIWDTLNGSL MKTISAHSEA VVSVDVPMND
     151  SSILSSGSYD GLIRIFDAET GHCLKTLTYD KDWKRENGVV PISQVKFSEN
     201  ARYLLVKSLD GVVKIWDCIG GCVVRTFQVQ PLEKGVLHHS CGMDFLNPED
     251  GSTPLVISGY ENGDIYCWNS DTKSLLQLLD GSLYHHSSPV MSIHCFGNIM
     301  CSLALNGDCC LWRWV*

external links for Swd3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Swd3p

1)	Roguev A, et al. (2001) The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J 20(24):7137-48
2)	Miller T, et al. (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7
3)	Nagy PL, et al. (2002) A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A 99(1):90-4
4)	Krogan NJ, et al. (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5
5)	Dover J, et al. (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71
6)	Cheng H, et al. (2004) The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol 24(7):2932-43