SEC66/YBR171W Protein Information

Standard Name	Sec66p
Systematic Name	Ybr171wp
Alias	Hss1p , Sec71p
ORF Classification	Verified
Description	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER (1)
Name Description	SECretory

Experimental Data
Molecules/cell	7820 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	206
Molecular Weight (Da)	24,231
Isoelectric Point (pI)	7.27

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sec66p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 48 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F92 \| P33754 MIPS: YBR171W NCBI: 312609 \| 392885 \| 398365265 \| 402609 \| 45270140 \| 464738 \| 536516 \| NP_009730.3 GenBank/EMBL/DDBJ: DAA07287.1 \| AY558125 \| U00797 \| X72224 \| X74437 \| Z36040

Amino Acid Sequence (or in FASTA format)
1 MSEFNETKFS NNGTFFETEE PIVETKSISV YTPLIYVFIL VVSLVMFASS 51 YRKKQAKKIS EQPSIFDEND AHDLYFQIKE MSENEKIHEK VLKAALLNRG 101 AESVRRSLKL KELAPQINLL YKNGSIGEDY WKRFETEVKL IELEFKDTLQ 151 EAERLQPGWV QLFVMVCKEI CFNQALSRRY QSILKRKEVC IKEWELKINN 201 DGRLVN*

Amino Acid Sequence (or in FASTA format)

       1  MSEFNETKFS NNGTFFETEE PIVETKSISV YTPLIYVFIL VVSLVMFASS
      51  YRKKQAKKIS EQPSIFDEND AHDLYFQIKE MSENEKIHEK VLKAALLNRG
     101  AESVRRSLKL KELAPQINLL YKNGSIGEDY WKRFETEVKL IELEFKDTLQ
     151  EAERLQPGWV QLFVMVCKEI CFNQALSRRY QSILKRKEVC IKEWELKINN
     201  DGRLVN*

external links for Sec66p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Sec66p

1)	Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41