SSE2/YBR169C Protein Information

Standard Name	Sse2p
Systematic Name	Ybr169cp
ORF Classification	Verified
Description	Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication (1, 2, 3)

Experimental Data
Molecules/cell	6300 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	693
Molecular Weight (Da)	77,620
Isoelectric Point (pI)	5.38

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sse2p (InterPro)
Physical Interactions	There are 52 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052EE2 \| P32590 MIPS: YBR169C NCBI: 312611 \| 417152 \| 51013211 \| 536512 \| 550540 \| 551302 \| 6319646 \| NP_009728.1 GenBank/EMBL/DDBJ: DAA07285.1 \| AY692880 \| D38369 \| D38371 \| X72224 \| Z36038

Amino Acid Sequence (or in FASTA format)
1 MSTPFGLDLG NNNSVLAVAR NRGIDVVVNE VSNRSTPSLV GFGPRNRYLG 51 ESGKTKQTSN VKNTVENLKR IIGLKFKDPE FDIENKFFTS KLVQLKNGKV 101 GVEVEFGGKT HVFSATQLTA MFIDKVKHTV QEETKSSITD VCLAVPVWYS 151 EEQRYNIADA ARIAGLNPVR IVNDVTAAAV SYGVFKNDLP GPEEKPRIIG 201 LVDIGHSTYT CSIMAFRKGE MKVLGTAYDK HFGGRDFDRA ITEHFADQFK 251 DKYKIDIRKN PKAYNRILIA AEKLKKVLSA NTTAPFSVES VMDDIDVSSQ 301 LSREELEELV EPLLKRVTYP ITNALAQAKL TVNDIDFVEI IGGTTRIPVL 351 KKSISDVFGK PLSSTLNQDE AVAKGAAFIC AIHSPTLRVR PFKFEDIDPY 401 SVSYTWDKQV DDEDRLEVFP ANSSYPSTKL ITLHRTGDFS MKAVYTHPSK 451 LPKGTSTTIA KWSFTGVKVP KDQDFIPVKV KLRCDPSGLH IIENAYTTED 501 ITVQEPVPLP EDAPEDAEPQ FKEVTKTIKK DVLGMTAKTF ALNPVELNDL 551 IEKENELRNQ DKLVAETEDR KNALEEYIYT LRAKLDDEYS DFASDAEKEK 601 LKNMLATTEN WLYGDGDDST KAKYIAKYEE LASLGNIIRG RYLAKEEEKR 651 QALRANQETS KMNDIAEKLA EQRRARAASD DSDDNNDENM DLD*

Amino Acid Sequence (or in FASTA format)

       1  MSTPFGLDLG NNNSVLAVAR NRGIDVVVNE VSNRSTPSLV GFGPRNRYLG
      51  ESGKTKQTSN VKNTVENLKR IIGLKFKDPE FDIENKFFTS KLVQLKNGKV
     101  GVEVEFGGKT HVFSATQLTA MFIDKVKHTV QEETKSSITD VCLAVPVWYS
     151  EEQRYNIADA ARIAGLNPVR IVNDVTAAAV SYGVFKNDLP GPEEKPRIIG
     201  LVDIGHSTYT CSIMAFRKGE MKVLGTAYDK HFGGRDFDRA ITEHFADQFK
     251  DKYKIDIRKN PKAYNRILIA AEKLKKVLSA NTTAPFSVES VMDDIDVSSQ
     301  LSREELEELV EPLLKRVTYP ITNALAQAKL TVNDIDFVEI IGGTTRIPVL
     351  KKSISDVFGK PLSSTLNQDE AVAKGAAFIC AIHSPTLRVR PFKFEDIDPY
     401  SVSYTWDKQV DDEDRLEVFP ANSSYPSTKL ITLHRTGDFS MKAVYTHPSK
     451  LPKGTSTTIA KWSFTGVKVP KDQDFIPVKV KLRCDPSGLH IIENAYTTED
     501  ITVQEPVPLP EDAPEDAEPQ FKEVTKTIKK DVLGMTAKTF ALNPVELNDL
     551  IEKENELRNQ DKLVAETEDR KNALEEYIYT LRAKLDDEYS DFASDAEKEK
     601  LKNMLATTEN WLYGDGDDST KAKYIAKYEE LASLGNIIRG RYLAKEEEKR
     651  QALRANQETS KMNDIAEKLA EQRRARAASD DSDDNNDENM DLD*

external links for Sse2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Sse2p

1)	Mukai H, et al. (1993) Isolation and characterization of SSE1 and SSE2, new members of the yeast HSP70 multigene family. Gene 132(1):57-66
2)	Shaner L, et al. (2004) The function of the yeast molecular chaperone Sse1 is mechanistically distinct from the closely related hsp70 family. J Biol Chem 279(21):21992-2001
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41