CDC28/YBR160W Protein Information 
| Standard Name | Cdc28p 1, 2 |
|---|---|
| Systematic Name | Ybr160wp |
| Alias | Cdk1p , Hsl5p , Srm5p |
| ORF Classification | Verified |
| Description | Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1 (CLNs), S and G2/M (CLBs) phase cyclins, which provide substrate specificity; regulates cell cycle transcriptional programs, basal transcription, chromosome duplication and segregation, spindle dynamics, lipid biosynthesis, membrane trafficking, polarized cell growth, and morphogenesis; abundance increases in response to DNA replication stress (10, 11, 12, 13, 14, 3, 4, 5, 6, 7, 8, 9) |
| Name Description | Cell Division Cycle 15 |
| Experimental Data | |
|---|---|
| Molecules/cell | 6670 16 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Cdc28p (InterPro) |
| Physical Interactions | There are 570 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI0000052F53 | P00546 MIPS: YBR160W NCBI: 115915 | 3486 | 398365175 | 535469 | 536494 | NP_009718.3 | NM_001178508.3 GenBank/EMBL/DDBJ: DAA07275.1 | X00257 | X80224 | Z36029 |
| External Classifications | EC: 2.7.11.22 [Cyclin-dependent kinase] |
external links for Cdc28p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| Aspergillus (AspGD) | BioPIXIE | MIPS | YeastRC Public Image Repository |
| Candida (CGD) | CYC2008 (complexes) | Pfam domains | |
| Candida (CandidaDB) | Complexome | YeastRC Structure Prediction (Seattle) | |
| YGOB | DIP | ||
| YOGY | GeneMANIA | ||
| YeastRC Two-Hybrid (Seattle) |
References cited on this page View Complete Literature Guide for Cdc28p
| 1) | Nasmyth KA and Reed SI (1980) Isolation of genes by complementation in yeast: molecular cloning of a cell-cycle gene. Proc Natl Acad Sci U S A 77(4):2119-23 |
| 2) | Hartwell LH, et al. (1973) Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants. Genetics 74(2):267-286 |
| 3) | Reed SI (1980) The selection of S. cerevisiae mutants defective in the start event of cell division. Genetics 95(3):561-77 |
| 4) | Mendenhall MD and Hodge AE (1998) Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae. Microbiol Mol Biol Rev 62(4):1191-243 |
| 5) | Reed SI and Wittenberg C (1990) Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 87(15):5697-701 |
| 6) | Wittenberg C, et al. (1990) G1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase. Cell 62(2):225-37 |
| 7) | Purnapatre K, et al. (2002) The CLN3/SWI6/CLN2 pathway and SNF1 act sequentially to regulate meiotic initiation in Saccharomyces cerevisiae. Genes Cells 7(7):675-91 |
| 8) | Benjamin KR, et al. (2003) Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. Genes Dev 17(12):1524-39 |
| 9) | Hartwell LH (1973) Three additional genes required for deoxyribonucleic acid synthesis in Saccharomyces cerevisiae. J Bacteriol 115(3):966-74 |
| 10) | Kurat CF, et al. (2009) Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol Cell 33(1):53-63 |
| 11) | Enserink JM and Kolodner RD (2010) An overview of Cdk1-controlled targets and processes. Cell Div 5():11 |
| 12) | Chymkowitch P, et al. (2012) Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes. Proc Natl Acad Sci U S A 109(26):10450-5 |
| 13) | McCusker D, et al. (2012) Cdk1-dependent control of membrane-trafficking dynamics. Mol Biol Cell 23(17):3336-47 |
| 14) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 15) | Hartwell LH, et al. (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9 |
| 16) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
