IFA38/YBR159W Protein Information

Standard Name	Ifa38p 1
Systematic Name	Ybr159wp
ORF Classification	Verified
Description	Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides (2, 3)

Experimental Data
Molecules/cell	41900 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	347
Molecular Weight (Da)	38,708
Isoelectric Point (pI)	10.28

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ifa38p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 136 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013A1BE \| P38286 MIPS: YBR159W NCBI: 45269627 \| 536492 \| 586299 \| 6319635 \| NP_009717.1 \| NM_001178507.1 GenBank/EMBL/DDBJ: DAA07274.1 \| AY557868 \| Z36028
External Classifications	EC: 1.-.-.- [Oxidoreductases] EC: 1.1.1.330 [Very-long-chain 3-oxoacyl-CoA reductase]

Amino Acid Sequence (or in FASTA format)
1 MTFMQQLQEA GERFRCINGL LWVVFGLGVL KCTTLSLRFL ALIFDLFLLP 51 AVNFDKYGAK TGKYCAITGA SDGIGKEFAR QMAKRGFNLV LISRTQSKLE 101 ALQKELEDQH HVVVKILAID IAEDKESNYE SIKELCAQLP ITVLVNNVGQ 151 SHSIPVPFLE TEEKELRNII TINNTATLLI TQIIAPKIVE TVKAENKKSG 201 TRGLILTMGS FGGLIPTPLL ATYSGSKSFL QGWSNSLAGE LSKDAIDVEL 251 IISYLVTSSM SKIRRSSLMI PNPQQFVKST LRSVGRRCGS QERYATMTPY 301 WAHAVYQFVI TETFGVYSKI VNSINYSFHK SIRIRALKKA ARQVKKE*

Amino Acid Sequence (or in FASTA format)

       1  MTFMQQLQEA GERFRCINGL LWVVFGLGVL KCTTLSLRFL ALIFDLFLLP
      51  AVNFDKYGAK TGKYCAITGA SDGIGKEFAR QMAKRGFNLV LISRTQSKLE
     101  ALQKELEDQH HVVVKILAID IAEDKESNYE SIKELCAQLP ITVLVNNVGQ
     151  SHSIPVPFLE TEEKELRNII TINNTATLLI TQIIAPKIVE TVKAENKKSG
     201  TRGLILTMGS FGGLIPTPLL ATYSGSKSFL QGWSNSLAGE LSKDAIDVEL
     251  IISYLVTSSM SKIRRSSLMI PNPQQFVKST LRSVGRRCGS QERYATMTPY
     301  WAHAVYQFVI TETFGVYSKI VNSINYSFHK SIRIRALKKA ARQVKKE*

external links for Ifa38p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ifa38p

1)	Gopalacharyulu PV, et al. (2009) Dynamic network topology changes in functional modules predict responses to oxidative stress in yeast. Mol Biosyst 5(3):276-87
2)	Beaudoin F, et al. (2002) A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. J Biol Chem 277(13):11481-8
3)	Han G, et al. (2002) The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase. J Biol Chem 277(38):35440-9
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41