MEC1/YBR136W Protein Information 
| Standard Name | Mec1p 1 |
|---|---|
| Systematic Name | Ybr136wp |
| Alias | Esr1p 2 , Sad3p , Rad31p 3 |
| ORF Classification | Verified |
| Description | Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate both dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres (1, 10, 2, 4, 5, 6, 7, 8, 9) |
| Name Description | Mitosis Entry Checkpoint 1 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Mec1p (InterPro) |
| Physical Interactions | There are 85 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI000012A1D6 | P38111 MIPS: YBR136W NCBI: 398365009 | 496866 | 506876 | 536430 | 586545 | 950173 | NP_009694.3 GenBank/EMBL/DDBJ: DAA07252.1 | D11088 | U31109 | X75891 | Z36005 |
| External Classifications | EC: 2.7.11.1 [Non-specific serine/threonine protein kinase] |
external links for Mec1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| Candida (CGD) | BioPIXIE | MIPS | |
| Candida (CandidaDB) | CYC2008 (complexes) | Pfam domains | |
| YGOB | Complexome | YeastRC Structure Prediction (Seattle) | |
| YOGY | DIP | ||
| GeneMANIA |
References cited on this page View Complete Literature Guide for Mec1p
| 1) | Weinert TA, et al. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8(6):652-65 |
| 2) | Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 |
| 3) | Kozhina TN, et al. (2011) [Gene RAD31 is identical to gene MEC1 of yeast Saccharomyces cerevisiae]. Genetika 47(5):610-4 |
| 4) | Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20 |
| 5) | Kiser GL and Weinert TA (1996) Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7(5):703-18 |
| 6) | Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-72 |
| 7) | Weinert T (1998) DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev 8(2):185-93 |
| 8) | Hector RE, et al. (2012) Mec1p associates with functionally compromised telomeres. Chromosoma 121(3):277-90 |
| 9) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 10) | Gupta A, et al. (2013) Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools. Genetics 193(4):1095-105 |
