TPS1/YBR126C Protein Information Help

Standard Name Tps1p 1, 2
Systematic Name Ybr126cp
Alias Byp1p , Cif1p , Fdp1p , Ggs1p , Glc6p , Tss1p
ORF Classification Verified
Description Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid (3, 4, 5, 6, 7)
Name Description Trehalose-6-Phosphate Synthase
Experimental Data
Molecules/cell 10900 8
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 495
Molecular Weight (Da) 56,147
Isoelectric Point (pI) 6.02

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Tps1p (InterPro)
Physical Interactions There are 70 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052E96 | Q00764
MIPS: YBR126C
NCBI: 3540 | 401206 | 4627 | 575398 | 6319602 | 808824 | NP_009684.1 | NM_001178474.1
GenBank/EMBL/DDBJ: DAA07243.1 | AF061037 | AY598964 | AY598966 | AY693147 | J04450 | L21999 | X61275 | X67499 | X68214 | X68496 | X75891 | X78993 | Z35995
External Classifications EC: 2.4.1.15 [Alpha,alpha-trehalose-phosphate synthase (UDP-forming)]
Amino Acid Sequence (or in FASTA format)
 
       1  MTTDNAKAQL TSSSGGNIIV VSNRLPVTIT KNSSTGQYEY AMSSGGLVTA
      51  LEGLKKTYTF KWFGWPGLEI PDDEKDQVRK DLLEKFNAVP IFLSDEIADL
     101  HYNGFSNSIL WPLFHYHPGE INFDENAWLA YNEANQTFTN EIAKTMNHND
     151  LIWVHDYHLM LVPEMLRVKI HEKQLQNVKV GWFLHTPFPS SEIYRILPVR
     201  QEILKGVLSC DLVGFHTYDY ARHFLSSVQR VLNVNTLPNG VEYQGRFVNV
     251  GAFPIGIDVD KFTDGLKKES VQKRIQQLKE TFKGCKIIVG VDRLDYIKGV
     301  PQKLHAMEVF LNEHPEWRGK VVLVQVAVPS RGDVEEYQYL RSVVNELVGR
     351  INGQFGTVEF VPIHFMHKSI PFEELISLYA VSDVCLVSST RDGMNLVSYE
     401  YIACQEEKKG SLILSEFTGA AQSLNGAIIV NPWNTDDLSD AINEALTLPD
     451  VKKEVNWEKL YKYISKYTSA FWGENFVHEL YSTSSSSTSS SATKN*

external links for Tps1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Tps1p
1) Luyte, K., et al.  (1992) Personal Communication, Mortimer Map Edition 11
2) Pringle, J.  (1985) Personal Communication, Mortimer Map Edition 9
3) Winderickx J, et al.  (1996) Regulation of genes encoding subunits of the trehalose synthase complex in Saccharomyces cerevisiae: novel variations of STRE-mediated transcription control? Mol Gen Genet 252(4):470-82
4) Bell W, et al.  (1992) Characterization of the 56-kDa subunit of yeast trehalose-6-phosphate synthase and cloning of its gene reveal its identity with the product of CIF1, a regulator of carbon catabolite inactivation. Eur J Biochem 209(3):951-9
5) Bell W, et al.  (1998) Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex. J Biol Chem 273(50):33311-9
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Schmidt M, et al.  (2012) Role of Hog1, Tps1 and Sod1 in boric acid tolerance of Saccharomyces cerevisiae. Microbiology 158(Pt 10):2667-78
8) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41