CMD1/YBR109C Protein Information Help

Standard Name Cmd1p 1
Systematic Name Ybr109cp
ORF Classification Verified
Description Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin (2, 3, 4, 5, 6, 7, 8, 9) Also known as: CaM 10
Name Description CalMoDulin
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 147
Molecular Weight (Da) 16,135
Isoelectric Point (pI) 4.01

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cmd1p (InterPro)
Physical Interactions There are 181 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000001D7 | P06787
MIPS: YBR109C
NCBI: 115533 | 171249 | 30749421 | 34811355 | 34811356 | 3800843 | 402550024 | 402550025 | 45270258 | 476065 | 536373 | 6319585 | NP_009667.1
GenBank/EMBL/DDBJ: DAA07228.1 | AF081667 | AY558184 | M14760 | X78993 | Z35978
Amino Acid Sequence (or in FASTA format)
 
       1  MSSNLTEEQI AEFKEAFALF DKDNNGSISS SELATVMRSL GLSPSEAEVN
      51  DLMNEIDVDG NHQIEFSEFL ALMSRQLKSN DSEQELLEAF KVFDKNGDGL
     101  ISAAELKHVL TSIGEKLTDA EVDDMLREVS DGSGEINIQQ FAALLSK*

external links for Cmd1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Cmd1p
1) Davis, T.  (1992) Personal Communication, Mortimer Map Edition 11
2) Kubler E, et al.  (1994) Calcium-independent calmodulin requirement for endocytosis in yeast. EMBO J 13(23):5539-46
3) Davis TN, et al.  (1986) Isolation of the yeast calmodulin gene: calmodulin is an essential protein. Cell 47(3):423-31
4) Ohya Y and Botstein D  (1994) Diverse essential functions revealed by complementing yeast calmodulin mutants. Science 263(5149):963-6
5) Starovasnik MA, et al.  (1993) Similarities and differences between yeast and vertebrate calmodulin: an examination of the calcium-binding and structural properties of calmodulin from the yeast Saccharomyces cerevisiae. Biochemistry 32(13):3261-70
6) Peters C and Mayer A  (1998) Ca2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion. Nature 396(6711):575-80
7) Cyert MS  (2001) Genetic analysis of calmodulin and its targets in Saccharomyces cerevisiae. Annu Rev Genet 35:647-72
8) Desrivieres S, et al.  (2002) Calmodulin controls organization of the actin cytoskeleton via regulation of phosphatidylinositol (4,5)-bisphosphate synthesis in Saccharomyces cerevisiae. Biochem J 366(Pt 3):945-51
9) Starai VJ, et al.  (2005) Ion regulation of homotypic vacuole fusion in Saccharomyces cerevisiae. J Biol Chem 280(17):16754-62
10) Spang A, et al.  (1996) The spacer protein Spc110p targets calmodulin to the central plaque of the yeast spindle pole body. J Cell Sci 109 ( Pt 9)():2229-37