FES1/YBR101C Protein Information

Standard Name	Fes1p
Systematic Name	Ybr101cp
ORF Classification	Verified
Description	Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress (1, 2)

Experimental Data
Molecules/cell	13100 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	290
Molecular Weight (Da)	32,604
Isoelectric Point (pI)	4.76

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Fes1p (InterPro)
Physical Interactions	There are 19 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004F8D9 \| P38260 MIPS: YBR101C NCBI: 398364783 \| 476057 \| 51013451 \| 536384 \| 586527 \| NP_009659.3 GenBank/EMBL/DDBJ: DAA07220.1 \| AY693000 \| X78993 \| Z35970

Amino Acid Sequence (or in FASTA format)
1 MEKLLQWSIA NSQGDKEAMA RAGQPDPKLL QQLFGGGGPD DPTLMKESMA 51 VIMNPEVDLE TKLVAFDNFE MLIENLDNAN NIENLKLWEP LLDVLVQTKD 101 EELRAAALSI IGTAVQNNLD SQNNFMKYDN GLRSLIEIAS DKTKPLDVRT 151 KAFYALSNLI RNHKDISEKF FKLNGLDCIA PVLSDNTAKP KLKMRAIALL 201 TAYLSSVKID ENIISVLRKD GVIESTIECL SDESNLNIID RVLSFLSHLI 251 SSGIKFNEQE LHKLNEGYKH IEPLKDRLNE DDYLAVKYVL *

Amino Acid Sequence (or in FASTA format)

       1  MEKLLQWSIA NSQGDKEAMA RAGQPDPKLL QQLFGGGGPD DPTLMKESMA
      51  VIMNPEVDLE TKLVAFDNFE MLIENLDNAN NIENLKLWEP LLDVLVQTKD
     101  EELRAAALSI IGTAVQNNLD SQNNFMKYDN GLRSLIEIAS DKTKPLDVRT
     151  KAFYALSNLI RNHKDISEKF FKLNGLDCIA PVLSDNTAKP KLKMRAIALL
     201  TAYLSSVKID ENIISVLRKD GVIESTIECL SDESNLNIID RVLSFLSHLI
     251  SSGIKFNEQE LHKLNEGYKH IEPLKDRLNE DDYLAVKYVL *

external links for Fes1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Fes1p

1)	Kabani M, et al. (2002) Nucleotide exchange factor for the yeast Hsp70 molecular chaperone Ssa1p. Mol Cell Biol 22(13):4677-89
2)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41