RXT2/YBR095C Protein Information

Standard Name	Rxt2p 1, 2
Systematic Name	Ybr095cp
Alias	Raf60p 3
ORF Classification	Verified
Description	Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth (2, 4)

Experimental Data
Molecules/cell	1630 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	430
Molecular Weight (Da)	48,629
Isoelectric Point (pI)	4.65

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rxt2p (InterPro)
Physical Interactions	There are 81 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001D4765 \| P38255 MIPS: YBR095C NCBI: 108935903 \| 37362619 \| 4087 \| 476053 \| 51012821 \| 536369 \| 586522 \| NP_009653.2 GenBank/EMBL/DDBJ: DAA07216.1 \| AY692685 \| X69881 \| X78993 \| Z35964

Amino Acid Sequence (or in FASTA format)
1 MTIRSSMKNN AELESKSVLA NESNIISTFT RRIIKEKSGN YQVLKRSLDG 51 KLIYPEATGI SSNRGNKLLQ RSEVVTRRDL NNSKPMIEQT VFYNGSEHRL 101 LQTNIVTDSR RKRIKFTPDI NVEPVLVGDE NDIDGSEKED ENITDEYYGE 151 EDDDDLSKLV NVKEILTPIL SLGDIINHKT ISRTFSSPIL KNLALQIILM 201 IEKEQMSVVR YSQFLEVFLG DHPEPIYESN LNLPSYNHNL TLPEDRGASD 251 EDDINNKNNI NEVNSNSLST EAGHINNGME EFGEEDPFFA LPRLEQSNAL 301 LSLLPSSSGS ASISTLTAAE QQQLNEEIES ARQLSQIALQ RNKEFIRNLQ 351 KIRKSVIKAN RIRGRILNWS REYLGISDDD ITIPVALRVV KRGLISATTN 401 KTTNFEEEIE NTMEDGVVDD NEPDEEANRA *

Amino Acid Sequence (or in FASTA format)

       1  MTIRSSMKNN AELESKSVLA NESNIISTFT RRIIKEKSGN YQVLKRSLDG
      51  KLIYPEATGI SSNRGNKLLQ RSEVVTRRDL NNSKPMIEQT VFYNGSEHRL
     101  LQTNIVTDSR RKRIKFTPDI NVEPVLVGDE NDIDGSEKED ENITDEYYGE
     151  EDDDDLSKLV NVKEILTPIL SLGDIINHKT ISRTFSSPIL KNLALQIILM
     201  IEKEQMSVVR YSQFLEVFLG DHPEPIYESN LNLPSYNHNL TLPEDRGASD
     251  EDDINNKNNI NEVNSNSLST EAGHINNGME EFGEEDPFFA LPRLEQSNAL
     301  LSLLPSSSGS ASISTLTAAE QQQLNEEIES ARQLSQIALQ RNKEFIRNLQ
     351  KIRKSVIKAN RIRGRILNWS REYLGISDDD ITIPVALRVV KRGLISATTN
     401  KTTNFEEEIE NTMEDGVVDD NEPDEEANRA *

external links for Rxt2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Rxt2p

1)	Schaft, D, et al. (2002) personal communication
2)	Carrozza MJ, et al. (2005) Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim Biophys Acta 1731(2):77-87; discussion 75-6
3)	Colina AR and Young D (2005) Raf60, a novel component of the Rpd3 histone deacetylase complex required for Rpd3 activity in Saccharomyces cerevisiae. J Biol Chem 280(52):42552-6
4)	Entian KD, et al. (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41