TIM12/YBR091C Protein Information Help

Standard Name Tim12p 1
Systematic Name Ybr091cp
Alias Mrs5p 2
ORF Classification Verified
Description Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins (2, 3)
Name Description Translocase of the Inner Membrane 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 109
Molecular Weight (Da) 12,284
Isoelectric Point (pI) 6.72

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Tim12p (InterPro)
Physical Interactions There are 21 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012F58F | P32830
MIPS: YBR091C
NCBI: 172072 | 417316 | 45270948 | 476049 | 536361 | 6319567 | NP_009649.1
GenBank/EMBL/DDBJ: DAA07212.1 | AY558529 | M90689 | X78993 | Z35960
Amino Acid Sequence (or in FASTA format)
 
       1  MSFFLNSLRG NQEVSQEKLD VAGVQFDAMC STFNNILSTC LEKCIPHEGF
      51  GEPDLTKGEQ CCIDRCVAKM HYSNRLIGGF VQTRGFGPEN QLRHYSRFVA
     101  KEIADDSKK*

external links for Tim12p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Tim12p
1) Sirrenberg C, et al.  (1998) Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5. Nature 391(6670):912-5
2) Jarosch E, et al.  (1996) Mrs5p, an essential protein of the mitochondrial intermembrane space, affects protein import into yeast mitochondria. J Biol Chem 271(29):17219-25
3) Rehling P, et al.  (2003) Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science 299(5613):1747-51