SEC18/YBR080C Protein Information Help

Standard Name Sec18p 1, 2
Systematic Name Ybr080cp
Alias Anu4p
ORF Classification Verified
Description ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF (3, 4, 5, 6)
Name Description SECretory 7
Experimental Data
Molecules/cell 5920 8
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 758
Molecular Weight (Da) 84,055
Isoelectric Point (pI) 8.08

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sec18p (InterPro)
Physical Interactions There are 64 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001355CD | P18759
MIPS: YBR080C
NCBI: 172563 | 172564 | 2580608 | 398364665 | 433846 | 536340 | 585965 | 6730184 | 6730185 | 6730186 | NP_009636.3
GenBank/EMBL/DDBJ: DAA07199.1 | AF004912 | M20662 | X76294 | Z35949
Amino Acid Sequence (or in FASTA format)
 
       1  MFKIPGFGKA AANHTPPDMT NMDTRTRHLK VSNCPNNSYA LANVAAVSPN
      51  DFPNNIYIII DNLFVFTTRH SNDIPPGTIG FNGNQRTWGG WSLNQDVQAK
     101  AFDLFKYSGK QSYLGSIDID ISFRARGKAV STVFDQDELA KQFVRCYESQ
     151  IFSPTQYLIM EFQGHFFDLK IRNVQAIDLG DIEPTSAVAT GIETKGILTK
     201  QTQINFFKGR DGLVNLKSSN SLRPRSNAVI RPDFKFEDLG VGGLDKEFTK
     251  IFRRAFASRI FPPSVIEKLG ISHVKGLLLY GPPGTGKTLI ARKIGTMLNA
     301  KEPKIVNGPE ILSKYVGSSE ENIRNLFKDA EAEYRAKGEE SSLHIIIFDE
     351  LDSVFKQRGS RGDGTGVGDN VVNQLLAKMD GVDQLNNILV IGMTNRKDLI
     401  DSALLRPGRF EVQVEIHLPD EKGRLQIFDI QTKKMRENNM MSDDVNLAEL
     451  AALTKNFSGA EIEGLVKSAS SFAINKTVNI GKGATKLNTK DIAKLKVTRE
     501  DFLNALNDVT PAFGISEEDL KTCVEGGMML YSERVNSILK NGARYVRQVR
     551  ESDKSRLVSL LIHGPAGSGK TALAAEIALK SGFPFIRLIS PNELSGMSES
     601  AKIAYIDNTF RDAYKSPLNI LVIDSLETLV DWVPIGPRFS NNILQMLKVA
     651  LKRKPPQDRR LLIMTTTSAY SVLQQMDILS CFDNEIAVPN MTNLDELNNV
     701  MIESNFLDDA GRVKVINELS RSCPNFNVGI KKTLTNIETA RHDEDPVNEL
     751  VELMTQSA*

external links for Sec18p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Sec18p
1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Fields, C. and Schekman, R.  (1985) Personal Communication, Mortimer Map Edition 9
3) Wilson DW, et al.  (1989) A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast. Nature 339(6223):355-9
4) Newman AP and Ferro-Novick S  (1990) Defining components required for transport from the ER to the Golgi complex in yeast. Bioessays 12(10):485-91
5) Mayer A, et al.  (1996) Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles. Cell 85(1):83-94
6) Ungermann C, et al.  (1998) A vacuolar v-t-SNARE complex, the predominant form in vivo and on isolated vacuoles, is disassembled and activated for docking and fusion. J Cell Biol 140(1):61-9
7) Novick P and Schekman R  (1979) Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(4):1858-62
8) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41