NRG2/YBR066C Protein Information Help

Standard Name Nrg2p 1
Systematic Name Ybr066cp
ORF Classification Verified
Description Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication (2, 3, 4)
Name Description Negative Regulator of Glucose-controlled genes 1
Experimental Data
Molecules/cell 704 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 220
Molecular Weight (Da) 25,009
Isoelectric Point (pI) 10.61

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Nrg2p (InterPro)
Physical Interactions There are 8 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000130509 | P38082
MIPS: YBR066C
NCBI: 51013175 | 536312 | 586505 | 6319540 | NP_009622.1 | NM_001178414.1
GenBank/EMBL/DDBJ: AAT92881.1 | CAA85010.1 | DAA07185.1 | AY692862 | Z35935
Amino Acid Sequence (or in FASTA format)
       1  MSIGYKDNLM STILAKDRKC EFPINFECSP SQITLMPEMF SFNNERKYQT
      51  LIPLMKTSHL IDDDLKDKLN KCAFDFFSGK QANRTSDGTI SRLTASGKTS
     101  PILPLQNINI VKAENTGNGK SDPYSSIKIS KPTKTVIKLK STKTNTAGQR
     151  TRHFCKICST GFTTSGHLSR HNRIHTGEKN HICPHEGCGQ RFSRHDNCNQ
     201  HYRTHANKKK RNWKRREASS *                               

external links for Nrg2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Candida (CGD) CYC2008 (complexes) MIPS YPL+
YGOB Complexome Pfam domains YeastGFP
YOGY DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Nrg2p
1) Zhou H and Winston F  (2001) NRG1 is required for glucose repression of the SUC2 and GAL genes of Saccharomyces cerevisiae. BMC Genet 2():5
2) Vyas VK, et al.  (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72
3) Kuchin S, et al.  (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41