AKL1/YBR059C Protein Information Help

Standard Name Akl1p 1
Systematic Name Ybr059cp
ORF Classification Verified
Description Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization (1, 2)
Name Description Ark family Kinase-Like protein 1
Experimental Data
Molecules/cell 3000 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,108
Molecular Weight (Da) 123,989
Isoelectric Point (pI) 7.73

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Akl1p (InterPro)
Physical Interactions There are 109 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012DC5A | P38080
MIPS: YBR059C
NCBI: 536299 | 585348 | 6319533 | NP_009615.1
GenBank/EMBL/DDBJ: DAA07179.1 | Z35928
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSITNGTSRS VSAMGHPAVE RYTPGHIVCV GTHKVEVVNY LAEGGFAQIY
      51  VVKFLEYLNE FDNTASVPLK IGDVACLKRV LVQDENGLNE MRNEVEVMKK
     101  LKGAPNIVQY FDSNASRRRD GVQGFEVLLL MELCPNKSLL DYMNQRLSTK
     151  LTEAEIVKIM YDVALSISQM HYLPVSLIHR DIKIENVLVD AKNNFKLADF
     201  GSTSTCFPIV TTHQDIALLT QNIYVHTTPQ YRSPEMIDLY RCLPINEKSD
     251  IWALGVFLYK LLFFTTPFEM TGQFAILHSK YEFPVNKYSS KLINLIIIML
     301  AENPNLRPNI YQVLYHLCEI LNVEVPIEDK YAEGAYNFSK YTQFQNKLQN
     351  VQLQMYQLQQ KKIMQNNKLS DSEENLLNDM FLSSFEISSK LPMNASDGHA
     401  AVSRIPSQNV GQELEEEKES QSDQRKSTLS EDKSSRTTSN ANSSGTANNP
     451  QEINTIQSPG IEDKSIFENK TPGELYYPSV SELDTYLDKE LVKQSSDPTI
     501  SEQSPRLNTQ SLPQRQKSTS SYSSGGRSMK STSYGAATIG SDEALANEKT
     551  AGINKMKQHK SNNPFPKMNV AYHSTNELSN DASNFFLEEQ QQGQRYQQAQ
     601  NQTGTQGNTF PDESQYQSRV EQQQQQQDQP KGPANYSQRN FYTGRDRSNK
     651  PMQLGGTIAG DSGNRRVNFQ NISQNYATNS QSGYLPSQNS PAIPMVRPVI
     701  SMNQQQAQQI QAQQLQAQQM QAKQQMQAKQ QMQVQQQLQV QQQMQIQNAN
     751  NNGTYVSDRT NHTTEDMRNA QGGEPPILAG NSANEPMHSS SKNEALLIEL
     801  SPLKEDAGKQ SFQDTNEPQT GGIEDAGGSG TIKGSNNNRN GVLNLSLNEM
     851  DLSRDDTGAA VSSFSSSSSS ASIQQAKLSG RKGSSKRNNY STDELGDSMV
     901  SSESIDIDLD DARRGKTAER RPLHNERGHK DQARSSDASK SNQFKSKDFS
     951  SVSTRQPRQS LDLNFQEVNL SSPTLTQEHR NKNDSPAPNS HHSYRVSPHA
    1001  STAITENKRH STGHELSTRS NGKHETHRTG SKQRHDLERY RHSKDKDSNS
    1051  SITISTSTPS EMRKSFARAR QSLDLERVRR EAMASSASSS GGSNGKRRSF
    1101  FSVFRSEK*

external links for Akl1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Akl1p
1) Cope MJ, et al.  (1999) Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast. J Cell Biol 144(6):1203-18
2) Henry KR, et al.  (2003) The actin-regulating kinase Prk1p negatively regulates Scd5p, a suppressor of clathrin deficiency, in actin organization and endocytosis. Curr Biol 13(17):1564-9
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41