REG2/YBR050C Protein Information

Standard Name	Reg2p 1
Systematic Name	Ybr050cp
ORF Classification	Verified
Description	Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease; REG2 has a paralog, REG1, that arose from the whole genome duplication (1, 2, 3)
Name Description	REsistance to Glucose repression 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	338
Molecular Weight (Da)	38,747
Isoelectric Point (pI)	8.14

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Reg2p (InterPro)
Physical Interactions	There are 7 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004F8D6 \| P38232 MIPS: YBR050C NCBI: 45269625 \| 536282 \| 559946 \| 586493 \| 6319525 \| NP_009606.1 GenBank/EMBL/DDBJ: DAA07170.1 \| AY557867 \| Z35919 \| Z46260

Amino Acid Sequence (or in FASTA format)
1 MTLSNCDSLD NLFQDPPEEE ESSKFVEAVR TLMNRNDMGY PPAAANGTYC 51 LKKIKSLNAK QWKINKKRMC MLPAVKKKNF DFHEQRSLIL NLNLWKFIKF 101 INCSSKNNYN KNNKHVRSSN NTVKNENVLP LQKHKKVDND QRLENLFWRS 151 WFKARKRRDI MGKPRERHIK FNDNVEQCII TDEHFIQRLP STRLNSTDEQ 201 RPCSKSELDP CIGNAASKRS FYDYNSVYVA SDAIITTAAA TAIISSNSGD 251 YQRGHDVRDV PRNVLLQAGE TDFSSVLRVD SDLKLSNISH HSPVKPSSTS 301 SHSTFIFESE TDTDTDTDAE TENDIDAYID TSIPNLLL*

Amino Acid Sequence (or in FASTA format)

       1  MTLSNCDSLD NLFQDPPEEE ESSKFVEAVR TLMNRNDMGY PPAAANGTYC
      51  LKKIKSLNAK QWKINKKRMC MLPAVKKKNF DFHEQRSLIL NLNLWKFIKF
     101  INCSSKNNYN KNNKHVRSSN NTVKNENVLP LQKHKKVDND QRLENLFWRS
     151  WFKARKRRDI MGKPRERHIK FNDNVEQCII TDEHFIQRLP STRLNSTDEQ
     201  RPCSKSELDP CIGNAASKRS FYDYNSVYVA SDAIITTAAA TAIISSNSGD
     251  YQRGHDVRDV PRNVLLQAGE TDFSSVLRVD SDLKLSNISH HSPVKPSSTS
     301  SHSTFIFESE TDTDTDTDAE TENDIDAYID TSIPNLLL*

external links for Reg2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Reg2p

1)	Frederick DL and Tatchell K (1996) The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growth. Mol Cell Biol 16(6):2922-31
2)	Jiang H, et al. (2000) Protein phosphatase type-1 regulatory subunits Reg1p and Reg2p act as signal transducers in the glucose-induced inactivation of maltose permease in Saccharomyces cerevisiae. Mol Gen Genet 263(3):411-22
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61