REG2/YBR050C Protein Information Help

Standard Name Reg2p 1
Systematic Name Ybr050cp
ORF Classification Verified
Description Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease; REG2 has a paralog, REG1, that arose from the whole genome duplication (1, 2, 3)
Name Description REsistance to Glucose repression 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 338
Molecular Weight (Da) 38,747
Isoelectric Point (pI) 8.14

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Reg2p (InterPro)
Physical Interactions There are 7 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000004F8D6 | P38232
MIPS: YBR050C
NCBI: 45269625 | 536282 | 559946 | 586493 | 6319525 | NP_009606.1 | NM_001178398.1
GenBank/EMBL/DDBJ: AAS56193.1 | CAA84994.1 | CAA86393.1 | DAA07170.1 | AY557867 | Z35919 | Z46260
Amino Acid Sequence (or in FASTA format)
       1  MTLSNCDSLD NLFQDPPEEE ESSKFVEAVR TLMNRNDMGY PPAAANGTYC
      51  LKKIKSLNAK QWKINKKRMC MLPAVKKKNF DFHEQRSLIL NLNLWKFIKF
     101  INCSSKNNYN KNNKHVRSSN NTVKNENVLP LQKHKKVDND QRLENLFWRS
     151  WFKARKRRDI MGKPRERHIK FNDNVEQCII TDEHFIQRLP STRLNSTDEQ
     201  RPCSKSELDP CIGNAASKRS FYDYNSVYVA SDAIITTAAA TAIISSNSGD
     251  YQRGHDVRDV PRNVLLQAGE TDFSSVLRVD SDLKLSNISH HSPVKPSSTS
     301  SHSTFIFESE TDTDTDTDAE TENDIDAYID TSIPNLLL*            

external links for Reg2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
YGOB CYC2008 (complexes) MIPS YPL+
YOGY Complexome Pfam domains YeastGFP

DIP


GeneMANIA


IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Reg2p
1) Frederick DL and Tatchell K  (1996) The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growth. Mol Cell Biol 16(6):2922-31
2) Jiang H, et al.  (2000) Protein phosphatase type-1 regulatory subunits Reg1p and Reg2p act as signal transducers in the glucose-induced inactivation of maltose permease in Saccharomyces cerevisiae. Mol Gen Genet 263(3):411-22
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61