QDR3/YBR043C Protein Information Help

Standard Name Qdr3p 1
Systematic Name Ybr043cp
Alias Aqr2p 2
ORF Classification Verified
Description Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin (1, 3, 4, 5)
Name Description QuiniDine Resistance 1
Experimental Data
Molecules/cell 279 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 689
Molecular Weight (Da) 77,286
Isoelectric Point (pI) 7.84

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Qdr3p (InterPro)
Transmembrane Domains There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 6 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0001F7BD2D | P38227
MIPS: YBR043C
NCBI: 330443425 | 341941782 | 536268 | 586486 | NP_009599.2
GenBank/EMBL/DDBJ: DAA07163.2 | Z35912
External Classifications TC: 2.A.1.2 [The Drug:H+ Antiporter-1 (12 Spanner) (DHA1) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MQAQGSQSNV GSLRSNCSDN SLPNNHVMMH CDESSGSPHS EHNDYSYEKT
      51  NLESTASNSR EHRDNQLSRL KSEEYVVPKN QRRGLLPQLA IIPEFKDARD
     101  YPPMMKKMIV FLIAFSSMMG PMGTSIIFPA INSITTEFKT SVIMVNVSIG
     151  VYLLSLGVFP LWWSSLSELE GRRTTYITSF ALLFAFNIGS ALAPDINSFI
     201  ALRMLCGAAS ASVQSVGAGT VADLYISEDR GKNLSYYYLG PLLAPLLSPI
     251  FGSLLVNRWP WRSTQWFMVI LSGCNVILLT VLLPETLRKQ DSKGAIAQIL
     301  AERRIQVDNN ERGEIQEDYQ RGEDETDRIE NQVATLSTEK HNYVGEVRDQ
     351  DSLDLESHSS PNTYDGRAGE TQLQRIYTEA SRSLYEYQLD DSGIDATTAQ
     401  VTRIRSTDPK LARSIRENSL RKLQTNLEEQ VKKVLSSNGG EIAPKQVSAV
     451  RKVWDTFFVY FIKPLKSLHF LEYPPVALAI TFSAISFSTV YFVNMTVEYK
     501  YSRPPYNFKP LYIGLLYIPN SVTYFFASIY GGRWVDMLLK RYKEKYGILA
     551  PEARISWNVV TSVISFPIAL LIFGWCLDKK CHWVTPLIGT ALFGYAAMMT
     601  IGATLSYLVD SLPGKGATGV ALNNLIRQIL AATAVFVTTP MLNGMGTGWA
     651  FTMLAFIVLG ASSVLIILKK HGDYWRENYD LQKLYDKID*

external links for Qdr3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome TCDB
YGOB DIP YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Qdr3p
1) Tenreiro S, et al.  (2005) The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin. Biochem Biophys Res Commun 327(3):952-9
2) Barz T, et al.  (2003) Genome-wide expression screens indicate a global role for protein kinase CK2 in chromatin remodeling. J Cell Sci 116(Pt 8):1563-77
3) Rieger KJ, et al.  (1999) Chemotyping of yeast mutants using robotics. Yeast 15(10B):973-86
4) Dias PJ, et al.  (2010) Evolution of the 12-Spanner Drug:H+ Antiporter DHA1 Family in Hemiascomycetous Yeasts. OMICS 14(6):701-10
5) Teixeira MC, et al.  (2011) Yeast response and tolerance to polyamine toxicity involving the drug : H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4. Microbiology 157(Pt 4):945-56
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41