SCO1/YBR037C Protein Information

Standard Name	Sco1p
Systematic Name	Ybr037cp
Alias	Pet161p
ORF Classification	Verified
Description	Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Suppressor of Cytochrome Oxidase deficiency 5

Experimental Data
Molecules/cell	2550 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	295
Molecular Weight (Da)	33,166
Isoelectric Point (pI)	9.8

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sco1p (InterPro)
Physical Interactions	There are 7 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013566B \| P23833 MIPS: YBR037C NCBI: 134307 \| 45269617 \| 536256 \| 6319511 \| 666104 \| 99031874 \| 99031875 \| 99031876 \| 99031877 \| 99031878 \| 99031879 \| 99031880 \| 99031881 \| NP_009593.1 GenBank/EMBL/DDBJ: DAA07157.1 \| AY557863 \| X17441 \| Z35906

Amino Acid Sequence (or in FASTA format)
1 MLKLSRSANL RLVQLPAARL SGNGAKLLTQ RGFFTVTRLW QSNGKKPLSR 51 VPVGGTPIKD NGKVREGSIE FSTGKAIALF LAVGGALSYF FNREKRRLET 101 QKEAEANRGY GKPSLGGPFH LEDMYGNEFT EKNLLGKFSI IYFGFSNCPD 151 ICPDELDKLG LWLNTLSSKY GITLQPLFIT CDPARDSPAV LKEYLSDFHP 201 SILGLTGTFD EVKNACKKYR VYFSTPPNVK PGQDYLVDHS IFFYLMDPEG 251 QFVDALGRNY DEKTGVDKIV EHVKSYVPAE QRAKQKEAWY SFLFK*

Amino Acid Sequence (or in FASTA format)

       1  MLKLSRSANL RLVQLPAARL SGNGAKLLTQ RGFFTVTRLW QSNGKKPLSR
      51  VPVGGTPIKD NGKVREGSIE FSTGKAIALF LAVGGALSYF FNREKRRLET
     101  QKEAEANRGY GKPSLGGPFH LEDMYGNEFT EKNLLGKFSI IYFGFSNCPD
     151  ICPDELDKLG LWLNTLSSKY GITLQPLFIT CDPARDSPAV LKEYLSDFHP
     201  SILGLTGTFD EVKNACKKYR VYFSTPPNVK PGQDYLVDHS IFFYLMDPEG
     251  QFVDALGRNY DEKTGVDKIV EHVKSYVPAE QRAKQKEAWY SFLFK*

external links for Sco1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Sco1p

1)	Rentzsch A, et al. (1999) Mitochondrial copper metabolism in yeast: mutational analysis of Sco1p involved in the biogenesis of cytochrome c oxidase. Curr Genet 35(2):103-8
2)	Nittis T, et al. (2001) Yeast Sco1, a protein essential for cytochrome c oxidase function is a Cu(I)-binding protein. J Biol Chem 276(45):42520-6
3)	Balatri E, et al. (2003) Solution structure of Sco1: a thioredoxin-like protein Involved in cytochrome c oxidase assembly. Structure 11(11):1431-43
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5)	Schulze M and Rodel G (1989) Accumulation of the cytochrome c oxidase subunits I and II in yeast requires a mitochondrial membrane-associated protein, encoded by the nuclear SCO1 gene. Mol Gen Genet 216(1):37-43
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41