HMT1/YBR034C Protein Information 
| Standard Name | Hmt1p 1 |
|---|---|
| Systematic Name | Ybr034cp |
| Alias | Hcp1p , Odp1p 2 , Rmt1p 3 |
| ORF Classification | Verified |
| Description | Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. (1, 3, 4, 5, 6, 7, 8) |
| Name Description | HnRNP MethylTransferase 1 |
| Experimental Data | |
|---|---|
| Molecules/cell | 37600 9 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Hmt1p (InterPro) |
| Physical Interactions | There are 162 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI0000049723 | P38074 MIPS: YBR034C NCBI: 12084699 | 12084700 | 12084701 | 12084702 | 12084703 | 12084704 | 440581 | 45269629 | 498761 | 536250 | 585608 | 6319508 | NP_009590.1 GenBank/EMBL/DDBJ: DAA07154.1 | AY557869 | X76078 | X76992 | Z35903 |
| External Classifications | EC: 2.1.1.- [Transferases transferring one-carbon groups methyltransferases] |
external links for Hmt1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | Organelle DB |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YPL+ |
| Aspergillus (AspGD) | BioPIXIE | MIPS | YeastGFP |
| Candida (CGD) | CYC2008 (complexes) | Pfam domains | YeastRC Public Image Repository |
| Candida (CandidaDB) | Complexome | YeastRC Structure Prediction (Seattle) | |
| YGOB | DIP | ||
| YOGY | GeneMANIA | ||
| YeastRC Two-Hybrid (Seattle) |
References cited on this page View Complete Literature Guide for Hmt1p
| 1) | Henry MF and Silver PA (1996) A novel methyltransferase (Hmt1p) modifies poly(A)+-RNA-binding proteins. Mol Cell Biol 16(7):3668-78 |
| 2) | Loubbardi A, et al. (1995) Sterol uptake induced by an impairment of pyridoxal phosphate synthesis in Saccharomyces cerevisiae: cloning and sequencing of the PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase. J Bacteriol 177(7):1817-23 |
| 3) | Gary JD, et al. (1996) The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae. J Biol Chem 271(21):12585-94 |
| 4) | Shen EC, et al. (1998) Arginine methylation facilitates the nuclear export of hnRNP proteins. Genes Dev 12(5):679-91 |
| 5) | Lipson RS, et al. (2010) Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae. Biochem Biophys Res Commun 391(4):1658-62 |
| 6) | Wong CM, et al. (2010) Yeast arginine methyltransferase Hmt1p regulates transcription elongation and termination by methylating Npl3p. Nucleic Acids Res 38(7):2217-28 |
| 7) | Chen YC, et al. (2010) Protein Arginine Methylation Facilitates Cotranscriptional Recruitment of Pre-mRNA Splicing Factors. Mol Cell Biol 30(21):5245-56 |
| 8) | Milliman EJ, et al. (2012) Recruitment of rpd3 to the telomere depends on the protein arginine methyltransferase hmt1. PLoS One 7(8):e44656 |
| 9) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
